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晚期胃癌治疗中预测和预后生物标志物的演变。

Evolution of predictive and prognostic biomarkers in the treatment of advanced gastric cancer.

机构信息

Merck & Co., Inc., 90 E. Scott Avenue, Rahway, NJ, 07065, USA.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Chiba, Japan.

出版信息

J Cancer Res Clin Oncol. 2022 Aug;148(8):2023-2043. doi: 10.1007/s00432-021-03902-1. Epub 2022 May 13.

DOI:10.1007/s00432-021-03902-1
PMID:35551464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11110882/
Abstract

Despite new therapeutic options, advanced gastric cancer remains associated with a poor prognosis compared with other cancers. Recent gains in the treatment of gastric cancer were accompanied by the identification of novel biomarkers associated with various cellular pathways and corresponding diagnostic technologies. It is expected that the standardization of clinical workflow and technological refinements in biomarker assessment will support greater personalization and further improve treatment outcomes. In this article, we review the current state of prognostic and predictive biomarkers in gastric cancer.

摘要

尽管有新的治疗选择，但与其他癌症相比，晚期胃癌的预后仍然较差。胃癌治疗的最新进展伴随着与各种细胞通路相关的新型生物标志物的发现和相应的诊断技术。预计临床工作流程的标准化和生物标志物评估技术的改进将支持更大程度的个性化，并进一步改善治疗效果。本文综述了胃癌预后和预测生物标志物的现状。