Medical School, Xi'an Peihua University, Xi'an 710125, Shaanxi, China.
School of Chemical Engineering and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, China.
Org Biomol Chem. 2022 Jun 1;20(21):4278-4288. doi: 10.1039/d2ob00671e.
Cyclodextrin (CD) and pillar[]arene are significant macrocyclic host molecules in supramolecular chemistry, and have either similar or contrasting physicochemical properties, for example, both can provide capable cavities available for recognizing various favorite guest molecules, while they usually possess different solubility in aqueous solutions, and exhibit diverse chiral characteristics. To balance their similarity and differences inherited from each chemical structure and incorporate both advantages, the CD-pillar[]arene hybrid macrocyclic system was recently developed. In this review, we will focus on the preparation and application of CD-pillar[]arene hybrid macrocyclic systems. Both noncovalent interactions and covalent bonds were employed in the synthesis strategies of building the hybrid macrocyclic system, which was in the form of host-guest inclusion, self-assembly, conjugated molecules, and polymeric structures. Furthermore, the CD-pillar[]arene hybrid macrocyclic system has been primarily applied for the removal of organic pollutants from water, induced chirality, as well as photocatalysis due to the integration of both cavities from CD and pillar[]arene as hybrid hosts and chiral characteristics inherited from their chemical structures.
环糊精 (CD) 和柱芳烃是超分子化学中重要的大环主体分子，具有相似或相反的物理化学性质，例如，两者都可以提供能够识别各种喜欢的客体分子的能力腔，而它们通常在水溶液中的溶解度不同，并表现出不同的手性特征。为了平衡它们各自化学结构所继承的相似性和差异性，并结合两者的优势，最近开发了 CD-柱芳烃杂化大环体系。在这篇综述中，我们将重点介绍 CD-柱芳烃杂化大环体系的制备和应用。在构建杂化大环体系的合成策略中，既采用了非共价相互作用，也采用了共价键，其形式为主体-客体包合、自组装、共轭分子和聚合结构。此外，由于 CD 和柱芳烃作为杂化主体的空腔以及其化学结构所继承的手性特征的整合，CD-柱芳烃杂化大环体系主要应用于从水中去除有机污染物、诱导手性以及光催化。
