Qin Dongya, Bo Weichen, Zheng Xin, Hao Youjin, Li Bo, Zheng Jie, Liang Guizhao
Key Laboratory of Biorheological Science and Technology, Ministry of Education, Bioengineering College, Chongqing University, Chongqing 400044, China.
College of Life Sciences, Chongqing Normal University, Chingqing 401331, China.
Bioinformatics. 2022 Jun 13;38(12):3275-3280. doi: 10.1093/bioinformatics/btac323.
Food-derived bioactive peptides (FBPs) have demonstrated their significance in pharmaceuticals, diets and nutraceuticals, benefiting public health and global ecology. While significant efforts have been made to discover FBPs and to elucidate the underlying bioactivity mechanisms, there is lack of a systemic study of sequence-structure-activity relationship of FBPs in a large dataset.
Here, we construct a database of food-derived bioactive peptides (DFBP), containing a total of 6276 peptide entries in 31 types from different sources. Further, we develop a series of analysis tools for function discovery/repurposing, traceability, multifunctional bioactive exploration and physiochemical property assessment of peptides. Finally, we apply this database and data-mining techniques to discover new FBPs as potential drugs for cardiovascular diseases. The DFBP serves as a useful platform for not only the fundamental understanding of sequence-structure-activity of FBPs but also the design, discovery, and repurposing of peptide-based drugs, vaccines, materials and food ingredients.
DFBP service can be accessed freely via http://www.cqudfbp.net/. All data are incorporated into the article and its online supplementary material.
Supplementary data are available at Bioinformatics online.
食物源生物活性肽（FBPs）在制药、饮食和营养保健品领域已彰显其重要性，对公众健康和全球生态有益。尽管在发现FBPs及阐明其潜在生物活性机制方面已付出巨大努力，但在大数据集中缺乏对FBPs序列 - 结构 - 活性关系的系统性研究。
在此，我们构建了一个食物源生物活性肽数据库（DFBP），其中包含来自不同来源的31种类型的总共6276个肽条目。此外，我们开发了一系列用于肽的功能发现/重新利用、可追溯性、多功能生物活性探索和理化性质评估的分析工具。最后，我们应用该数据库和数据挖掘技术来发现新的FBPs作为心血管疾病的潜在药物。DFBP不仅是深入理解FBPs序列 - 结构 - 活性的有用平台，也是基于肽的药物、疫苗、材料和食品成分的设计、发现和重新利用的有用平台。
可通过http://www.cqudfbp.net/免费访问DFBP服务。所有数据都包含在文章及其在线补充材料中。
补充数据可在《生物信息学》在线获取。
