Xiao Baichuan, Zhou Yixiang, Zhao Long, Huang Haodong, Fei Xuwen, Zhang Yong-Biao
School of Engineering Medicine, Beihang University, Beijing, 100191, China.
School of Materials and Chemical Engineering, Beijing Institute of Petrochemical Technology, Beijing, 102627, China.
Sci Data. 2025 Jul 14;12(1):1213. doi: 10.1038/s41597-025-05528-1.
This paper presents a comprehensive dataset comprising 58,583 experimentally validated therapeutic peptides with annotated structure information. These peptides are grouped into 47 categories based on their function or therapeutic property like antimicrobial or glucose-regulatory, of which 21,130 are multi-function peptides and 54,722 possess structural annotation information. We believe this dataset can be useful for the relevant research of therapeutic peptides, especially for computational tool developments in therapeutic peptide discovery and further exploration of the 'sequence-structure-function' relationship for therapeutic peptides.
本文展示了一个包含58583种经实验验证的治疗性肽的综合数据集，这些肽带有注释的结构信息。这些肽根据其功能或治疗特性（如抗菌或调节血糖）被分为47类，其中21130种是多功能肽，54722种具有结构注释信息。我们相信这个数据集对于治疗性肽的相关研究可能是有用的，特别是对于治疗性肽发现中的计算工具开发以及对治疗性肽“序列-结构-功能”关系的进一步探索。
