卡托普利加氢氯噻嗪每日一次可使原发性高血压患者的24小时血压正常化。
Captopril plus hydrochlorothiazide once daily normalizes 24 h blood pressure in patients with essential hypertension.
作者信息
Meijer J L, Ardesch H G, Van Rooijen J C, De Bruijn J H
出版信息
Br J Clin Pharmacol. 1987;23 Suppl 1(Suppl 1):83S-88S. doi: 10.1111/j.1365-2125.1987.tb03126.x.
The hypotensive effect of captopril 50 mg twice daily and of captopril 50 mg + hydrochlorothiazide (HCTZ) 25 mg once daily was studied in 12 patients with mild to moderate essential hypertension, whose blood pressure was not normalized by captopril 25 mg twice daily alone. Both captopril 50 mg twice daily and captopril 50 mg + HCTZ 25 mg once daily caused a significant reduction of outpatient blood pressures as compared with placebo (P less than 0.001). Captopril 50 mg + HCTZ 25 mg once daily also reduced outpatient blood pressures significantly when compared with captopril 25 mg twice daily (P less than 0.01). Both captopril 50 mg twice daily and captopril 50 mg + HCTZ 25 mg once daily significantly reduced 24 h blood pressure (P less than 0.001) without disturbance of its normal circadian rhythm. This effect was more pronounced while on captopril + HCTZ. Captopril 50 mg + HCTZ 25 mg once daily normalizes 24 h blood pressure in most patients with mild to moderate essential hypertension, whose blood pressure is not controlled by captopril 25 mg twice daily alone.
对12例轻度至中度原发性高血压患者进行了研究，这些患者单独使用每日2次、每次25 mg的卡托普利时血压未恢复正常。研究了每日2次、每次50 mg卡托普利以及每日1次、每次50 mg卡托普利 + 25 mg氢氯噻嗪（HCTZ）的降压效果。与安慰剂相比，每日2次、每次50 mg卡托普利以及每日1次、每次50 mg卡托普利 + 25 mg HCTZ均使门诊血压显著降低（P < 0.001）。与每日2次、每次25 mg卡托普利相比，每日1次、每次50 mg卡托普利 + 25 mg HCTZ也显著降低了门诊血压（P < 0.01）。每日2次、每次50 mg卡托普利以及每日1次、每次50 mg卡托普利 + 25 mg HCTZ均显著降低了24小时血压（P < 0.001），且未干扰其正常的昼夜节律。卡托普利 + HCTZ时这种效果更明显。每日1次、每次50 mg卡托普利 + 25 mg HCTZ可使大多数单独使用每日2次、每次25 mg卡托普利血压未得到控制的轻度至中度原发性高血压患者的24小时血压恢复正常。
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