Renlund D G, Gerstenblith G
Cardiol Clin. 1987 May;5(2):331-6.
Studies of the effect of age on cardiac function during exercise are confounded by the increasing prevalence of disease and sedentary lifestyle that accompany aging and by the lack of techniques to clearly distinguish between the contribution of changes in central circulatory and peripheral factors to the age-related alterations in cardiovascular physiology. Although diastolic filling is delayed at rest, end diastolic volume is not compromised either at rest or during exercise. Exercise heart rate is invariably reported to decrease with increasing age, whereas stroke volume has been reported to be both increased and decreased in studies of different populations. Most investigators report an increase in end systolic volume and a diminished ejection fraction in older individuals as well. These changes are mediated, in part, by an age-associated diminished responsiveness to beta-adrenergic stimulation.
关于年龄对运动中心脏功能影响的研究存在混淆因素，包括随着年龄增长疾病患病率增加、久坐不动的生活方式以及缺乏明确区分中心循环和外周因素变化对心血管生理中与年龄相关改变的贡献的技术。尽管静息时舒张期充盈延迟，但静息或运动时舒张末期容积并未受损。运动心率总是随年龄增长而降低，而在不同人群的研究中，每搏输出量既有增加的报道，也有减少的报道。大多数研究者还报告称，老年人的收缩末期容积增加，射血分数降低。这些变化部分是由与年龄相关的对β-肾上腺素能刺激反应性降低介导的。
