Gonçalves Dias Leonardo Francisco, Stamboroski Stephani, Noeske Michael, Salz Dirk, Rischka Klaus, Pereira Renata, Mainardi Maria do Carmo, Cardoso Marina Honorato, Wiesing Martin, Bronze-Uhle Erika Soares, Esteves Lins Rodrigo Barros, Lisboa-Filho Paulo Noronha
Fraunhofer Institute for Manufacturing Technology and Advanced Materials IFAM Bremen Germany
São Paulo State University - UNESP, School of Science, Department of Physics Brazil.
RSC Adv. 2020 Nov 2;10(65):39854-39869. doi: 10.1039/d0ra06511k. eCollection 2020 Oct 27.
Tailoring the surface properties of materials for biomedical applications is important to avoid clinical complications. Forming thin layers of amphiphilic molecules with apolar regions that facilitate attractive intermolecular interactions, can be a suitable and versatile approach to achieve hydrophobic surface modification and provide functional antibacterial properties. Aiming to correlate layer structure and properties starting from film formation, octadecylphosphonic acid (ODPA) and dimethyloctadecyl (3-trimethoxysilylpropyl) ammonium chloride (DMOAP) layers were adsorbed onto smooth titania surfaces. Then the films were studied by atomic force microscopy (AFM) and X-ray Photoelectron Spectroscopy (XPS), and their interactions with aqueous environments were characterized by contact angle and zeta potential measurements. In addition, antibacterial assays were performed using and to reveal the antibacterial properties effected by the surface modification. Immediately after sputter deposition, titania was hydrophilic; however, after air storage and adsorption of DMOAP or ODPA, an increase in the water contact angle was observed. XPS investigations after layer formation and after antibacterial tests revealed that the attachment of layers assembled from ODPA on titania substrates is considerably stronger and more stable than that observed for DMOAP films. Heat treatment strongly affects DMOAP layers. Furthermore, DMOAP layers are not stable under biological conditions.
为生物医学应用量身定制材料的表面特性对于避免临床并发症至关重要。形成具有促进分子间吸引相互作用的非极性区域的两亲分子薄层，可能是实现疏水表面改性并提供功能性抗菌性能的一种合适且通用的方法。为了从成膜开始关联层结构和性能，将十八烷基膦酸（ODPA）和二甲基十八烷基（3-三甲氧基甲硅烷基丙基）氯化铵（DMOAP）层吸附到光滑的二氧化钛表面上。然后通过原子力显微镜（AFM）和X射线光电子能谱（XPS）对薄膜进行研究，并通过接触角和zeta电位测量来表征它们与水性环境的相互作用。此外，使用 和 进行抗菌试验，以揭示表面改性所产生的抗菌性能。溅射沉积后，二氧化钛是亲水性的；然而，在空气储存以及DMOAP或ODPA吸附后，观察到水接触角增加。层形成后和抗菌测试后的XPS研究表明，由ODPA组装在二氧化钛基底上的层的附着比DMOAP薄膜的附着要强得多且更稳定。热处理对DMOAP层有强烈影响。此外，DMOAP层在生物条件下不稳定。
