Xi Fen, Feng Yuyi, Chen Qiaoli, Chen Liping, Liu Jianhua
The First Affiliated Hospital, Jinan University, Guangzhou, China.
Department of Ultrasound Medical, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China.
Front Oncol. 2022 Apr 26;12:852454. doi: 10.3389/fonc.2022.852454. eCollection 2022.
Sonodynamic therapy (SDT) is a promising treatment method for solid tumors. However, the high interstitial fluid pressure (IFP) in tumor tissues limits the accumulation of sonosensitizers. In the present study, microbubbles ultrasonic cavitation was used to regulate the tumor's IFP and evaluate SDT effects. Rabbit VX2 tumor tissues were treated with microbubbles ultrasonic cavitation. The IFP of different tumor parts before and after cavitation was measured by the WIN method. The accumulation of the sonosensitizers hematoporphyrin monomethyl ether (HMME) in tumor tissues was observed using an ultramicro spectrophotometer and laser confocal microscope. Then, tumor-bearing rabbits were treated with SDT once a week for eight weeks and the therapeutic effect was evaluated. After microbubbles ultrasonic cavitation treatment, the tumor's IFP decreased and the HMME concentration increased. We concluded that microbubbles ultrasonic cavitation can increase HMME accumulation in rabbit VX2 tumors and increase SDT therapeutic effects.
声动力疗法（SDT）是一种很有前景的实体肿瘤治疗方法。然而，肿瘤组织中较高的间质液压力（IFP）限制了声敏剂的积聚。在本研究中，利用微泡超声空化来调节肿瘤的IFP并评估SDT效果。对兔VX2肿瘤组织进行微泡超声空化处理。采用WIN法测量空化前后不同肿瘤部位的IFP。使用超微量分光光度计和激光共聚焦显微镜观察声敏剂血卟啉单甲醚（HMME）在肿瘤组织中的积聚情况。然后，对荷瘤兔每周进行一次SDT治疗，共治疗八周，并评估治疗效果。微泡超声空化处理后，肿瘤的IFP降低，HMME浓度增加。我们得出结论，微泡超声空化可增加HMME在兔VX2肿瘤中的积聚，并提高SDT治疗效果。
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