Amberlite - 15促进了前所未有的氮杂迈克尔重排反应，用于一锅法合成二氢喹唑啉酮化合物。
Amberlite-15 promoted an unprecedented aza Michael rearrangement for one pot synthesis of dihydroquinazolinone compounds.
作者信息
Murthy V Narayana, Nikumbh Satish P, Tadiparthi Krishnaji, Madhubabu M V, Jammula Subba Rao, Rao L Vaikunta, Raghunadh Akula
机构信息
Technology Development Centre, Custom Pharmaceutical Services, Dr Reddy's Laboratories Ltd Hyderabad 500049 India
Department of Chemistry, GIS, Gitam University Visakhapatnam 530045 India.
出版信息
RSC Adv. 2018 Jun 19;8(40):22331-22334. doi: 10.1039/c8ra03308k.
A new one pot multicomponent annulation strategy for the synthesis of various dihydroquinazolinone compounds has been developed using Amberlite-15 as a catalyst, giving good to moderate yields. In this reaction the substrate scope for amines and aldehydes was also investigated. The reaction has been checked on a large scale and the possible reaction mechanism has also been proposed.
已开发出一种以Amberlite-15为催化剂合成各种二氢喹唑啉酮化合物的新型一锅多组分环化策略，产率良好至中等。在该反应中，还研究了胺和醛的底物范围。该反应已进行了大规模验证，并提出了可能的反应机理。
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