μ-芋螺毒素lt5d的全合成

Naraga A M B, Belleza O J V, Villaraza A J L

Institute of Chemistry, College of Science, National Science Complex, University of the Philippines Diliman Quezon City 1100 Philippines

RSC Adv. 2018 Oct 30;8(64):36579-36583. doi: 10.1039/c8ra03706j. eCollection 2018 Oct 26.

The total synthesis of μ-conotoxin lt5d is presented for the first time employing two different strategies. One involves glutathione-assisted oxidation where all disulphide linkages are formed simultaneously. Another involves orthogonal protection of cysteine residues, allowing the controlled formation of disulphide linkages sequentially. Both methods achieve the same peptide.

首次采用两种不同策略实现了μ-芋螺毒素lt5d的全合成。一种方法涉及谷胱甘肽辅助氧化，其中所有二硫键同时形成。另一种方法涉及对半胱氨酸残基进行正交保护，从而允许二硫键依次可控形成。两种方法都得到了相同的肽。