Xu Jiangyan, Zhang Jinrong, Mao Qi-Fen, Wu Jian, Wang Yuan
Department of Laboratory Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Department of Science and Education, Dafeng District People's Hospital, Yancheng, China.
Front Genet. 2022 Apr 26;13:880359. doi: 10.3389/fgene.2022.880359. eCollection 2022.
Tumor is one of the important factors affecting human life and health in today's world, and scientists have studied it extensively and deeply, among which autophagy and JAK/STAT3 signaling pathway are two important research directions. The JAK/STAT3 axis is a classical intracellular signaling pathway that assumes a key role in the regulation of cell proliferation, apoptosis, and vascular neogenesis, and its abnormal cell signaling and regulation are closely related to the occurrence and development of tumors. Therefore, the JAK/STAT3 pathway in tumor cells and various stromal cells in their microenvironment is often considered as an effective target for tumor therapy. Autophagy is a process that degrades cytoplasmic proteins and organelles through the lysosomal pathway. It is a fundamental metabolic mechanism for intracellular degradation. The mechanism of action of autophagy is complex and may play different roles at various stages of tumor development. Altered STAT3 expression has been found to be accompanied by the abnormal autophagy activity in many oncological studies, and the two may play a synergistic or antagonistic role in promoting or inhibiting the occurrence and development of tumors. This article reviews the recent advances in autophagy and its interaction with JAK/STAT3 signaling pathway in the pathogenesis, prevention, diagnosis, and treatment of tumors.
肿瘤是当今世界影响人类生命健康的重要因素之一，科学家们对其进行了广泛而深入的研究，其中自噬和JAK/STAT3信号通路是两个重要的研究方向。JAK/STAT3轴是一条经典的细胞内信号通路，在细胞增殖、凋亡和血管新生的调节中起关键作用，其细胞信号传导和调节异常与肿瘤的发生发展密切相关。因此，肿瘤细胞及其微环境中各种基质细胞内的JAK/STAT3通路常被视为肿瘤治疗的有效靶点。自噬是一种通过溶酶体途径降解细胞质蛋白和细胞器的过程。它是细胞内降解的一种基本代谢机制。自噬的作用机制复杂，在肿瘤发展的各个阶段可能发挥不同作用。在许多肿瘤学研究中发现，STAT3表达改变伴随着自噬活性异常，二者在促进或抑制肿瘤发生发展过程中可能发挥协同或拮抗作用。本文综述了自噬及其与JAK/STAT3信号通路在肿瘤发病机制、预防、诊断和治疗方面相互作用的最新研究进展。
