Wang Xiaoping, Zhu Yanxia, Xie Qiuli
Department of Infectious Diseases, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.
Am J Transl Res. 2022 Apr 15;14(4):2749-2766. eCollection 2022.
The importance of microRNAs (miRNAs or miRs) has attracted more and more attention. MiRNA is an approximately 22-nucleotide, single-stranded, non-coding RNA molecule that affects the expression of downstream target genes. MiRNAs regulate the occurrence and development of human diseases. The objective of this article is to explore the abnormal expression of miR-198 in a variety of human diseases. The relationships between abnormally expressed miR-198 and clinicopathological characteristics are also summarized. Its roles in various diseases and potential molecular mechanisms include involvement in many biological processes, such as cell cycle regulation, proliferation, invasion, migration, apoptosis, and drug resistance. The potential value of miR-198 for disease diagnosis, treatment, and especially, prognosis, are discussed. More in-depth research on miRNA will support the conversion from basic research to clinical applications of this molecule.
微小RNA（miRNA或miR）的重要性已引起越来越多的关注。微小RNA是一种约22个核苷酸的单链非编码RNA分子，可影响下游靶基因的表达。微小RNA调节人类疾病的发生和发展。本文的目的是探讨miR-198在多种人类疾病中的异常表达。还总结了异常表达的miR-198与临床病理特征之间的关系。其在各种疾病中的作用和潜在分子机制包括参与许多生物学过程，如细胞周期调控、增殖、侵袭、迁移、凋亡和耐药性。讨论了miR-198在疾病诊断、治疗尤其是预后方面的潜在价值。对微小RNA进行更深入的研究将支持该分子从基础研究向临床应用的转化。
