Department of Chemotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, China.
J Cell Mol Med. 2022 Feb;26(4):977-989. doi: 10.1111/jcmm.17161. Epub 2022 Jan 11.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level. MiRNAs are involved in the development and progression of a wide range of cancers. Among such cancer-associated miRNAs, miR-381 has been a major focus of research. The expression pattern and role of miR-381 vary among different cancer types. MiR-381 modulates various cellular behaviours in cancer, including proliferation, apoptosis, cell cycle progression, migration and invasion. MiR-381 is also involved in angiogenesis and lymphangiogenesis, as well as in the resistance to chemotherapy and radiotherapy. MiR-381 itself is regulated by several factors, such as long noncoding RNAs, circular RNAs and cytokines. Aberrant expression of miR-381 in blood samples indicates that it can be used as a diagnostic marker in cancer. Tissue miR-381 expression may serve as a prognostic factor for the clinicopathological characteristics of cancers and survival of patients. Metformin and icaritin regulate miR-381 expression and present anticancer properties. This review comprehensively summarizes the effect of miR-381 on tumour biological behaviours, as well as the clinical application potential of miR-381 for the treatment of cancer.
微小 RNA（miRNAs）是一种小的非编码 RNA，可在转录后水平调控基因表达。miRNAs 参与多种癌症的发生和发展。在这些与癌症相关的 miRNAs 中，miR-381 是研究的重点。miR-381 的表达模式和作用在不同的癌症类型中有所不同。miR-381 调节癌症中多种细胞行为，包括增殖、凋亡、细胞周期进程、迁移和侵袭。miR-381 还参与血管生成和淋巴管生成，以及对化疗和放疗的抵抗。miR-381 本身受多种因素的调节，如长链非编码 RNA、环状 RNA 和细胞因子。血液样本中 miR-381 的异常表达表明它可以作为癌症的诊断标志物。组织 miR-381 的表达可作为癌症临床病理特征和患者生存的预后因素。二甲双胍和淫羊藿苷调节 miR-381 的表达，并具有抗癌特性。本综述全面总结了 miR-381 对肿瘤生物学行为的影响，以及 miR-381 治疗癌症的临床应用潜力。
