College of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China.
Small. 2022 Jun;18(24):e2201525. doi: 10.1002/smll.202201525. Epub 2022 May 12.
Limited permeability in solid tumors significantly restricts the anticancer efficacy of nanomedicines. Light-driven nanomotors powered by photothermal converting engines are appealing carriers for directional drug delivery and simultaneous phototherapy. Nowadays, it is still a great challenge to construct metal-free photothermal nanomotors for a programmable anticancer treatment. Herein, one kind of photoactivated organic nanomachines is reported with asymmetric geometry assembled by light-to-heat converting semiconducting polymer engine and macromolecular anticancer payload through a straightforward nanoprecipitation process. The NIR-fueled polymer engine can be remotely controlled to power the nanomachines for light-driven thermophoresis in the liquid media and simultaneously thermal ablating the cancer cells. The great manipulability of the nanomachines allows for programming of their self-propulsion in the tumor microenvironment for effectively improving cellular uptake and tumor penetration of the anticancer payload. Taking the benefit from this behavior, a programmed treatment process is established at a low drug dose and a low photothermal temperature for significantly enhancing the antitumor efficacy.
实体肿瘤的通透性有限，极大地限制了纳米药物的抗癌疗效。由光热转换引擎驱动的光驱动纳米马达是一种很有吸引力的药物定向输送和同时光疗的载体。如今，构建用于可编程抗癌治疗的无金属光热纳米马达仍然是一个巨大的挑战。在此，通过简单的纳米沉淀过程，报道了一种具有不对称几何形状的光激活有机纳米机器，由光热转换半导体聚合物引擎和高分子抗癌有效载荷组装而成。NIR 燃料的聚合物引擎可以远程控制，为纳米机器提供动力，使其在液体介质中进行光驱动热泳，并同时热消融癌细胞。纳米机器的高操控性允许对其在肿瘤微环境中的自推进进行编程，从而有效提高抗癌有效载荷的细胞摄取和肿瘤穿透性。利用这种行为，可以在低药物剂量和低光热温度下建立程序化治疗过程，显著提高抗肿瘤疗效。
