Gesu G P, Eftimiadi C, Debbia E, Schito G C
Drugs Exp Clin Res. 1987;13(2):79-84.
The antibacterial activity of quinolones and fluoroquinolones was evaluated against several strains of enterobacteria growing in Mueller-Hinton broth and in urine at different pH. The data obtained in alkaline urine and in Mueller-Hinton broth indicate that the MIC values of the fluoroquinolones are about 16-32 times inferior to those found in urine at pH 6. On the other hand, the activity of nalidixic acid and more particularly that of cinoxacin in urine appears to be optimum at this lower pH, showing MIC values only 2-4 times higher than those obtained in Mueller-Hinton media. Although the fluoroquinolones appear to have the highest degree of activity, a better MBC/MIC ratio was observed for cinoxacin and for nalidixic and oxolinic acids.
评估了喹诺酮类和氟喹诺酮类药物对在不同pH值的穆勒-欣顿肉汤和尿液中生长的几种肠杆菌菌株的抗菌活性。在碱性尿液和穆勒-欣顿肉汤中获得的数据表明，氟喹诺酮类药物的最低抑菌浓度（MIC）值比在pH值为6的尿液中发现的值低约16至32倍。另一方面，萘啶酸的活性，尤其是西诺沙星在尿液中的活性，在这个较低的pH值下似乎是最佳的，其MIC值仅比在穆勒-欣顿培养基中获得的值高2至4倍。尽管氟喹诺酮类药物似乎具有最高的活性程度，但西诺沙星、萘啶酸和恶喹酸的最低杀菌浓度（MBC）/最低抑菌浓度（MIC）比值更佳。
