有机光氧化还原催化烯烃的还原四氟烷基化反应。
Organophotoredox-Catalyzed Reductive Tetrafluoroalkylation of Alkenes.
机构信息
N. D. Zelinsky Institute of Organic Chemistry, Leninsky prosp. 47, 119991 Moscow, Russian Federation.
Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory 1-3, 119991 Moscow, Russian Federation.
出版信息
J Org Chem. 2023 May 19;88(10):6523-6531. doi: 10.1021/acs.joc.2c00712. Epub 2022 May 13.
A method for the hydroperfluoroalkylation of alkenes with 1,2-dibromotetrafluoroethane leading to tetrafluorinated bromides is described. The reaction is conveniently performed under blue light irradiation using an organic photocatalyst and ascorbic acid as a reducing agent. Primary products can be further functionalized via radical pathways affording various tetrafluorinated compounds.
描述了一种使用 1,2-二溴四氟乙烷将烯烃进行全氟烷基化生成四氟溴化物的方法。该反应在蓝光照射下，使用有机光催化剂和抗坏血酸作为还原剂，方便地进行。初级产物可以通过自由基途径进一步官能化，得到各种全氟化合物。
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