Felix Franciel Batista, Vago Juliana Priscila, Beltrami Vinícius Amorim, Araújo Jessica Maria Dantas, Grespan Renata, Teixeira Mauro Martins, Pinho Vanessa
Department of Morphology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Experimental Rheumatology, Department of Rheumatology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Pharmacol Res. 2022 Jun;180:106246. doi: 10.1016/j.phrs.2022.106246. Epub 2022 May 10.
Uncontrolled inflammation and failure to resolve the inflammatory response are crucial factors involved in the progress of inflammatory diseases. Current therapeutic strategies aimed at controlling excessive inflammation are effective in some cases, though they may be accompanied by severe side effects, such as immunosuppression. Phytochemicals as a therapeutic alternative can have a fundamental impact on the different stages of inflammation and its resolution. Biochanin A (BCA) is an isoflavone known for its wide range of pharmacological properties, especially its marked anti-inflammatory effects. Recent studies have provided evidence of BCA's abilities to activate events essential for resolving inflammation. In this review, we summarize the most recent findings from pre-clinical studies of the pharmacological effects of BCA on the complex signaling network associated with the onset and resolution of inflammation and BCA's potential protective functionality in several models of inflammatory diseases, such as arthritis, pulmonary disease, neuroinflammation, and metabolic disease.
不受控制的炎症以及炎症反应无法消退是炎症性疾病进展过程中的关键因素。目前旨在控制过度炎症的治疗策略在某些情况下是有效的，尽管它们可能伴随着严重的副作用，如免疫抑制。植物化学物质作为一种治疗选择，可能会对炎症及其消退的不同阶段产生根本性影响。生物活性成分A（BCA）是一种异黄酮，因其广泛的药理特性而闻名，尤其是其显著的抗炎作用。最近的研究提供了证据，证明BCA具有激活炎症消退所必需事件的能力。在这篇综述中，我们总结了临床前研究中关于BCA对与炎症发生和消退相关的复杂信号网络药理作用的最新发现，以及BCA在几种炎症性疾病模型（如关节炎、肺病、神经炎症和代谢疾病）中的潜在保护功能。
