适体：功能-结构研究与生物医学应用。
Aptamers: Functional-Structural Studies and Biomedical Applications.
机构信息
Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario di Monte Sant'Angelo, Via Cintia, I-80126 Naples, Italy.
出版信息
Int J Mol Sci. 2022 Apr 27;23(9):4796. doi: 10.3390/ijms23094796.
Abstract
Aptamers are synthetic molecules of different natures (mostly, DNA or RNA) that recognize a target molecule with high affinity and specificity [...].
摘要
适配体是不同性质的合成分子（大多数是 DNA 或 RNA），它们能以高亲和力和特异性识别靶分子[...]。
相似文献
1
Aptamers: Functional-Structural Studies and Biomedical Applications.适体：功能-结构研究与生物医学应用。
Int J Mol Sci. 2022 Apr 27;23(9):4796. doi: 10.3390/ijms23094796.
2
Progress in selection and biomedical applications of aptamers.适体的选择与生物医学应用进展。
J Biomed Nanotechnol. 2014 Oct;10(10):3043-62. doi: 10.1166/jbn.2014.1979.
3
In silico molecular docking in DNA aptamer development.在 DNA 适体开发中的计算机分子对接。
Biochimie. 2021 Jan;180:54-67. doi: 10.1016/j.biochi.2020.10.005. Epub 2020 Oct 18.
4
SELEX Modifications and Bioanalytical Techniques for Aptamer-Target Binding Characterization.SELEX 修饰和适体-靶标结合特性的生物分析技术。
Crit Rev Anal Chem. 2016 Nov;46(6):521-37. doi: 10.1080/10408347.2016.1157014. Epub 2016 Mar 15.
5
The Effects of SELEX Conditions on the Resultant Aptamer Pools in the Selection of Aptamers Binding to Bacterial Cells.SELEX条件对筛选与细菌细胞结合的适体过程中所得适体库的影响。
J Mol Evol. 2015 Dec;81(5-6):194-209. doi: 10.1007/s00239-015-9711-y. Epub 2015 Nov 4.
6
Aptamers from random sequence space: Accomplishments, gaps and future considerations.随机序列空间中的适体：成就、差距和未来的考虑。
Anal Chim Acta. 2022 Mar 1;1196:339511. doi: 10.1016/j.aca.2022.339511. Epub 2022 Jan 18.
7
An improved SELEX technique for selection of DNA aptamers binding to M-type 11 of Streptococcus pyogenes.一种用于筛选与化脓性链球菌M11型结合的DNA适配体的改良SELEX技术。
Methods. 2016 Mar 15;97:51-7. doi: 10.1016/j.ymeth.2015.12.005. Epub 2015 Dec 8.
8
In vitro selection of RNA aptamers for a small-molecule dye.用于小分子染料的RNA适配体的体外筛选。
Methods Mol Biol. 2014;1111:17-28. doi: 10.1007/978-1-62703-755-6_2.
9
Sequence-constructive SELEX: a new strategy for screening DNA aptamer binding to Globo H.序列构建性 SELEX：一种筛选与 Globo H 结合的 DNA 适体的新策略。
Biochem Biophys Res Commun. 2014 Sep 26;452(3):484-9. doi: 10.1016/j.bbrc.2014.08.086. Epub 2014 Aug 23.
10
Selection of Structure-Switching DNA Aptamers Binding Soluble Small Molecules and SPR Validation of Enrichment.结合可溶性小分子的结构转换DNA适配体的筛选及富集的表面等离子体共振验证
Methods Mol Biol. 2018;1811:183-197. doi: 10.1007/978-1-4939-8582-1_13.
引用本文的文献
1
Aptamers: Functional-Structural Studies and Biomedical Applications 2.0.适体：功能-结构研究与生物医学应用2.0
Int J Mol Sci. 2024 Apr 12;25(8):4279. doi: 10.3390/ijms25084279.
2
Structural Insights into Protein-Aptamer Recognitions Emerged from Experimental and Computational Studies.从实验和计算研究中揭示出蛋白-适体识别的结构见解。
Int J Mol Sci. 2023 Nov 14;24(22):16318. doi: 10.3390/ijms242216318.
3
New insight into the traditional model of the coagulation cascade and its regulation: illustrated review of a three-dimensional view.凝血级联反应传统模型及其调节的新见解：三维视角的图解综述
Res Pract Thromb Haemost. 2023 Aug 7;7(6):102160. doi: 10.1016/j.rpth.2023.102160. eCollection 2023 Aug.
4
Steric hindrance and structural flexibility shape the functional properties of a guanine-rich oligonucleotide.空间位阻和结构柔韧性塑造了富含鸟嘌呤的寡核苷酸的功能特性。
Nucleic Acids Res. 2023 Sep 8;51(16):8880-8890. doi: 10.1093/nar/gkad634.
5
A terminal functionalization strategy reveals unusual binding abilities of anti-thrombin anticoagulant aptamers.一种末端功能化策略揭示了抗凝血酶抗凝适体不同寻常的结合能力。
Mol Ther Nucleic Acids. 2022 Nov 15;30:585-594. doi: 10.1016/j.omtn.2022.11.007. eCollection 2022 Dec 13.
本文引用的文献
1
BSA Hydrogel Beads Functionalized with a Specific Aptamer Library for Capturing in Serum and Blood.BSA 水凝胶珠经特定适配体文库功能化用于从血清和血液中捕获 。
Int J Mol Sci. 2021 Oct 15;22(20):11118. doi: 10.3390/ijms222011118.
2
Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands.凝血酶的外切位点结合：适体和其他配体复合物的整体结构/动力学概述。
Int J Mol Sci. 2021 Oct 6;22(19):10803. doi: 10.3390/ijms221910803.
3
FluCell-SELEX Aptamers as Specific Binding Molecules for Diagnostics of the Health Relevant Gut Bacterium .FluCell-SELEX 适体作为用于诊断与健康相关肠道细菌的特异性结合分子。
Int J Mol Sci. 2021 Sep 27;22(19):10425. doi: 10.3390/ijms221910425.
4
Beyond G-Quadruplexes-The Effect of Junction with Additional Structural Motifs on Aptamers Properties.超越 G-四链体-连接其他结构模体对适体性质的影响。
Int J Mol Sci. 2021 Sep 14;22(18):9948. doi: 10.3390/ijms22189948.
5
Identification and Engineering of Aptamers for Theranostic Application in Human Health and Disorders.用于人类健康和疾病治疗诊断应用的适体的鉴定和工程化。
Int J Mol Sci. 2021 Sep 7;22(18):9661. doi: 10.3390/ijms22189661.
6
Charge-Transfer Interactions Stabilize G-Quadruplex-Forming Thrombin Binding Aptamers and Can Improve Their Anticoagulant Activity.电荷转移相互作用稳定形成 G-四链体的凝血酶结合适体，并能提高其抗凝活性。
Int J Mol Sci. 2021 Sep 2;22(17):9510. doi: 10.3390/ijms22179510.
7
Role of RNA Motifs in RNA Interaction with Membrane Lipid Rafts: Implications for Therapeutic Applications of Exosomal RNAs.RNA 基序在 RNA 与膜脂筏相互作用中的作用：外泌体 RNA 治疗应用的意义。
Int J Mol Sci. 2021 Aug 30;22(17):9416. doi: 10.3390/ijms22179416.
8
High-Throughput Selection and Characterisation of Aptamers on Optical Next-Generation Sequencers.高通量筛选和光学下一代测序仪上适配体的表征。
Int J Mol Sci. 2021 Aug 25;22(17):9202. doi: 10.3390/ijms22179202.
9
NXP031 Improves Cognitive Impairment in a Chronic Cerebral Hypoperfusion-Induced Vascular Dementia Rat Model through Nrf2 Signaling.NXP031通过Nrf2信号通路改善慢性脑灌注不足诱导的血管性痴呆大鼠模型中的认知障碍。
Int J Mol Sci. 2021 Jun 11;22(12):6285. doi: 10.3390/ijms22126285.
10
Structural Biology for the Molecular Insight between Aptamers and Target Proteins.适体与靶蛋白之间分子洞察力的结构生物学。
Int J Mol Sci. 2021 Apr 15;22(8):4093. doi: 10.3390/ijms22084093.
Zotero 插件