School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.
School of Nursing and Health, Henan University, Kaifeng 475004, China.
Int J Mol Sci. 2022 Apr 27;23(9):4818. doi: 10.3390/ijms23094818.
Nucleotide-binding oligomeric domain (NOD)-like receptor protein 3 (NLRP3) is a recently discovered cytoplasmic multiprotein complex involved in inflammation. The NLRP3 inflammasome contains NLRP3, apoptosis-related specific protein (ASC) and precursor caspase-1. The NLRP3 inflammasome is involved in many diseases, including diabetes. HS is a harmful gas with a rotten egg smell. Recently, it has been identified as the third gas signal molecule after nitric oxide and carbon monoxide. It has many biological functions and plays an important role in many diseases, including diabetes. In recent years, it has been reported that HS regulation of the NLRP3 inflammasome contributes to a variety of diseases. However, the mechanism has not been fully understood. In this review, we summarized the recent role and mechanism of HS in regulating the NLRP3 inflammasome in diabetes, in order to provide a theoretical basis for future research.
核苷酸结合寡聚结构域（NOD）样受体蛋白 3（NLRP3）是一种新发现的参与炎症的细胞质多蛋白复合物。NLRP3 炎性体包含 NLRP3、凋亡相关斑点样蛋白（ASC）和前体半胱天冬酶-1。NLRP3 炎性体参与多种疾病，包括糖尿病。HS 是一种具有臭鸡蛋气味的有害气体。最近，它被确定为继一氧化氮和一氧化碳之后的第三种气体信号分子。它具有许多生物学功能，在许多疾病中发挥着重要作用，包括糖尿病。近年来，有报道称 HS 调节 NLRP3 炎性体有助于多种疾病。然而，其机制尚未完全阐明。在这篇综述中，我们总结了 HS 调节 NLRP3 炎性体在糖尿病中的作用和机制，以期为今后的研究提供理论依据。
