Department of Life Sciences, Kyonggi University, Suwon 16227, Korea.
Int J Mol Sci. 2022 Apr 30;23(9):4986. doi: 10.3390/ijms23094986.
An inflammatory response consists of two consecutive steps: priming and triggering, to prepare and activate inflammatory responses, respectively. The cardinal feature of the triggering step is the activation of intracellular protein complexes called inflammasomes, which provide a platform for the activation of inflammatory signaling pathways. Despite many studies demonstrating the regulatory roles of canonical inflammasomes in inflammatory liver diseases, the roles of newly discovered non-canonical inflammasomes in inflammatory liver diseases are still largely unknown. Recent studies have reported the regulatory roles of the caspase-11 non-canonical inflammasome in inflammatory liver diseases, providing strong evidence that the caspase-11 non-canonical inflammasome may play key roles in the pathogenesis of inflammatory liver diseases. This review comprehensively discusses the emerging roles of the caspase-11 non-canonical inflammasome in the pathogenesis of inflammatory liver diseases, focusing on non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and inflammatory liver injuries and its underlying mechanisms. This review highlights the current knowledge on the regulatory roles of the caspase-11 non-canonical inflammasome in inflammatory liver diseases, providing new insights into the development of potential therapeutics to prevent and treat inflammatory liver diseases by targeting the caspase-11 non-canonical inflammasome.
致敏和触发，分别为炎症反应做准备和激活。触发步骤的主要特征是细胞内蛋白复合物的激活，称为炎性体，它为炎症信号通路的激活提供了一个平台。尽管许多研究表明经典炎性体在炎症性肝病中的调节作用，但新发现的非经典炎性体在炎症性肝病中的作用仍知之甚少。最近的研究报道了半胱天冬酶-11 非经典炎性体在炎症性肝病中的调节作用，为半胱天冬酶-11 非经典炎性体可能在炎症性肝病发病机制中发挥关键作用提供了有力证据。这篇综述全面讨论了半胱天冬酶-11 非经典炎性体在炎症性肝病发病机制中的新作用，重点讨论了非酒精性脂肪性肝病（NAFLD）、非酒精性脂肪性肝炎（NASH）和炎症性肝损伤及其潜在机制。这篇综述强调了目前对半胱天冬酶-11 非经典炎性体在炎症性肝病中的调节作用的认识，为通过靶向半胱天冬酶-11 非经典炎性体开发预防和治疗炎症性肝病的潜在治疗方法提供了新的见解。
