Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei 10617, Taiwan.
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
Cells. 2022 Apr 29;11(9):1492. doi: 10.3390/cells11091492.
Lysosomes are membrane-bound vesicles that play roles in the degradation and recycling of cellular waste and homeostasis maintenance within cells. False alterations of lysosomal functions can lead to broad detrimental effects and cause various diseases, including cancers. Cancer cells that are rapidly proliferative and invasive are highly dependent on effective lysosomal function. Malignant melanoma is the most lethal form of skin cancer, with high metastasis characteristics, drug resistance, and aggressiveness. It is critical to understand the role of lysosomes in melanoma pathogenesis in order to improve the outcomes of melanoma patients. In this mini-review, we compile our current knowledge of lysosomes' role in tumorigenesis, progression, therapy resistance, and the current treatment strategies related to lysosomes in melanoma.
溶酶体是一种具有膜结构的囊泡，在细胞内废物的降解和再循环以及维持细胞内环境稳定方面发挥着重要作用。溶酶体功能的错误改变会导致广泛的有害影响，并引发各种疾病，包括癌症。快速增殖和侵袭的癌细胞高度依赖于有效的溶酶体功能。恶性黑色素瘤是最致命的皮肤癌形式，具有高转移特性、耐药性和侵袭性。了解溶酶体在黑色素瘤发病机制中的作用对于改善黑色素瘤患者的预后至关重要。在这篇小型综述中，我们总结了目前关于溶酶体在肿瘤发生、进展、治疗耐药性以及与黑色素瘤相关的溶酶体治疗策略方面的作用的认识。
