Koshikawa N, Mori E, Oka K, Nomura H, Yatsushige N, Maruyama Y
J Nihon Univ Sch Dent. 1989 Jun;31(2):451-7. doi: 10.2334/josnusd1959.31.451.
The effects of SCH23390, a selective D1 receptor antagonist, injected into either the dorsal striatum or nucleus accumbens on methamphetamine-induced stereotyped gnawing and hyperlocomotion in rats were investigated. SCH23390 injected into the dorsal striatum did not alter the gnawing induced by both methamphetamine and apomorphine. However, SCH23390 injected into the nucleus accumbens significantly reduced methamphetamine-induced gnawing without altering the effects of apomorphine. Injection of SCH23390 into the nucleus accumbens reduced the hyperlocomotion produced by methamphetamine more markedly than injection of SCH23390 into the dorsal striatum.
研究了将选择性D1受体拮抗剂SCH23390注射到大鼠背侧纹状体或伏隔核中对甲基苯丙胺诱导的刻板啃咬和活动亢进的影响。注射到背侧纹状体的SCH23390并未改变甲基苯丙胺和阿扑吗啡诱导的啃咬行为。然而，注射到伏隔核的SCH23390显著减少了甲基苯丙胺诱导的啃咬行为，同时不改变阿扑吗啡的作用。与将SCH23390注射到背侧纹状体相比，将其注射到伏隔核更显著地减少了甲基苯丙胺产生的活动亢进。
