持久的 PARP1 激活介导信号诱导的基因表达。
A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression.
机构信息
The Sackler School of Medicine, Deptartment of Physiology and Pharmacology, Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 69978, Israel.
出版信息
Cells. 2022 May 7;11(9):1576. doi: 10.3390/cells11091576.
This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.
本文概述了最近的证据，表明 PARP1 可通过多种信号转导机制被长期激活，从而介导信号诱导的基因表达和染色质重塑。这种 PARP1 激活模式已在多种细胞类型中、生理条件下被报道。在这种机制中，PARP1 并非通过与 DNA 断裂结合而被短暂激活。此外，受损 DNA 会干扰这种长期的 PARP1 激活。
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