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信号诱导的 PARP1-Erk 协同作用介导 IEG 表达。

Signal-induced PARP1-Erk synergism mediates IEG expression.

机构信息

1Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, 69978 Israel.

2Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, 69978 Israel.

出版信息

Signal Transduct Target Ther. 2019 Apr 12;4:8. doi: 10.1038/s41392-019-0042-0. eCollection 2019.

DOI:10.1038/s41392-019-0042-0
PMID:30993015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6459926/
Abstract

A recently disclosed Erk-induced PARP1 activation mechanism mediates the expression of immediate early genes (IEGs) in response to a variety of extra- and intracellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. This binding maintains long-lasting synergistic activity of these proteins, which offers a new pattern for targeted therapy.

摘要

最近披露的 Erk 诱导的 PARP1 激活机制介导了即时早期基因 (IEGs) 的表达，以响应各种涉及记忆获取、发育和增殖的细胞外和细胞内信号。在这里，我们回顾了这一机制，该机制是由刺激诱导的 PARP1 与转位入核的磷酸化 Erk 结合引发的。这种结合保持了这些蛋白质的持久协同活性，为靶向治疗提供了一种新模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/60b12727c73f/41392_2019_42_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/672b499f8732/41392_2019_42_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/8ad6f39b3326/41392_2019_42_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/1e8451da4da2/41392_2019_42_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/60b12727c73f/41392_2019_42_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/672b499f8732/41392_2019_42_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/8ad6f39b3326/41392_2019_42_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/1e8451da4da2/41392_2019_42_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba6a/6459926/60b12727c73f/41392_2019_42_Fig4_HTML.jpg

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