Cui Shumao, Guo Weiling, Chen Cailing, Tang Xin, Zhao Jianxin, Mao Bingyong, Zhang Hao
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Foods. 2022 Apr 19;11(9):1187. doi: 10.3390/foods11091187.
Understanding the association between food composition and intestinal microbiota in the context of individual health is a critical problem in personalized nutrition. The objective of the present research was to elucidate the influence of ST-III and fructooligosaccharides (FOS) on the intestinal microbiota structure. We found that ST-III and FOS interventions remarkably enhanced the levels of cecal short-chain fatty acids (SCFAs), especially acetic, butyric, and valeric acids. Moreover, ST-III and/or FOS intervention obviously altered the intestinal microbiota structure. At the genus level, ST-III and/or FOS intervention remarkably elevated the proportion of , , , , and . Correlation analysis further uncovered that the specific compositional features of intestinal microbiota were strongly related to the concentration of cecal SCFAs. Our results offered scientific evidence to understanding the association between food composition and intestinal microbiota.
在个体健康背景下理解食物成分与肠道微生物群之间的关联是个性化营养中的一个关键问题。本研究的目的是阐明ST-III和低聚果糖（FOS）对肠道微生物群结构的影响。我们发现，ST-III和FOS干预显著提高了盲肠短链脂肪酸（SCFA）的水平，尤其是乙酸、丁酸和戊酸。此外，ST-III和/或FOS干预明显改变了肠道微生物群结构。在属水平上，ST-III和/或FOS干预显著提高了 、 、 、 、 和 的比例。相关性分析进一步发现，肠道微生物群的特定组成特征与盲肠SCFA的浓度密切相关。我们的结果为理解食物成分与肠道微生物群之间的关联提供了科学依据。
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