Hwangbo Seon-Ae, Lee Seung-Yul, Kim Bu-An, Moon Chang-Kwon
Nanosafety Team, Safety Measurement Institute, Korea Research Institute of Standards and Science (KRISS), 267 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea.
The Korea Ship and Offshore Research Institute, Pusan National University, Busan 46241, Korea.
Nanomaterials (Basel). 2022 May 3;12(9):1547. doi: 10.3390/nano12091547.
Emulsion technology is widely used in the preparation of cosmetics, pharmaceuticals, drug delivery, and other daily necessities, and surfactants are frequently used to prepare these emulsions because of the lack of reliable surfactant-free emulsification techniques. This is disadvantageous because some surfactants pose health hazards, cause environmental pollution, have costly components, and place limitations on process development. In this paper, an efficient method for surfactant-free nano-emulsification is presented. In addition, we discuss the effects of different operating parameters on the oil particle size, as well as the effect of the particle size on the emulsion stability. Specifically, we compared three surfactant-free ultrasonic emulsification technologies (horn, bath, and focused ultrasonic systems). The focused ultrasonic system, which concentrates sound energy at the center of the dispersion system, showed the best performance, producing emulsions with a particle size distribution of 60-400 nm at 400 kHz. In addition, phase separation did not occur despite the lack of surfactants and thickeners, and the emulsion remained stable for seven days. It is expected to be widely used in eco-friendly emulsification processes.
乳液技术广泛应用于化妆品、药品、药物递送及其他日用品的制备中，由于缺乏可靠的无表面活性剂乳化技术，表面活性剂常用于制备这些乳液。这是不利的，因为一些表面活性剂会对健康造成危害、导致环境污染、成分成本高，并对工艺开发有限制。本文提出了一种高效的无表面活性剂纳米乳化方法。此外，我们讨论了不同操作参数对油粒径的影响，以及粒径对乳液稳定性的影响。具体而言，我们比较了三种无表面活性剂超声乳化技术（喇叭型、浴槽型和聚焦超声系统）。聚焦超声系统将声能集中在分散系统的中心，表现出最佳性能，在400kHz时产生粒径分布为60 - 400nm的乳液。此外，尽管没有表面活性剂和增稠剂，相分离也未发生，乳液保持稳定七天。预计该技术将广泛应用于环保型乳化工艺。
