Ratto Fulvio, Magni Giada, Aluigi Annalisa, Giannelli Marta, Centi Sonia, Matteini Paolo, Oberhauser Werner, Pini Roberto, Rossi Francesca
Istituto di Fisica Applicata "Nello Carrara", Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino, FI, Italy.
Istituto per la Sintesi Organica e la Fotoreattività, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, BO, Italy.
Nanomaterials (Basel). 2022 May 9;12(9):1613. doi: 10.3390/nano12091613.
In spite of an extensive body of academic initiatives and innovative products, the toolkit of wound dressing has always revolved around a few common concepts such as adhesive patches and stitches and their variants. Our work aims at an alternative solution for an immediate restitutio ad integrum of the mechanical functionality in cutaneous repairs. We describe the fabrication and the application of electrospun mats of bioactive nanofibers all made of biocompatible components such as a natural polysaccharide and a cyanine dye for use as laser-activatable plasters, resembling the ultrastructure of human dermis. In particular, we investigate their morphological features and mechanical moduli under conditions of physiological relevance, and we test their use to bind a frequent benchmark of connective tissue as rabbit tendon and a significant case of clinical relevance as human dermis. Altogether, our results point to the feasibility of a new material for wound dressing combining translational potential, strength close to human dermis, extensibility exceeding 15% and state-of-art adhesive properties.
尽管有大量的学术研究和创新产品，但伤口敷料的工具包一直围绕着一些常见概念，如粘性贴片、缝线及其变体。我们的工作旨在为皮肤修复中机械功能的即时恢复提供一种替代解决方案。我们描述了由生物相容性成分（如天然多糖和花菁染料）制成的生物活性纳米纤维电纺垫的制备和应用，这些电纺垫用作激光可激活的膏药，类似于人类真皮的超微结构。特别是，我们研究了它们在生理相关条件下的形态特征和力学模量，并测试了它们用于结合结缔组织的常见基准（如兔肌腱）和临床相关的重要案例（如人类真皮）的情况。总之，我们的结果表明，一种用于伤口敷料的新材料具有可行性，该材料具有转化潜力、接近人类真皮的强度、超过15%的延伸性和先进的粘合性能。
