Smart L E, Platt D J, Timbury M C
Epidemiol Infect. 1987 Apr;98(2):203-9. doi: 10.1017/s0950268800061926.
The serotype distribution of 874 strains of Streptococcus pneumoniae was determined in relation to patients' age and to frequency of isolation from systemic disease. Types 14 and 18, in pre-school children, and types 1, 4, 7, 8 and 12 in patients over 5 years of age were significantly associated with systemic disease whereas type 23 in pre-school children, and type 6 in older patients was associated with upper respiratory tract carriage. No significant difference was found in the incidence of other types in systemic disease compared to upper respiratory tract carriage. Fifteen diagnostic pneumococcal antisera (to types 1, 3, 4, 6, 7, 8, 9, 11, 12, 14, 17, 18, 19, 22 and 23) sufficed for typing 87% of strains.
对874株肺炎链球菌进行血清型分布测定，分析其与患者年龄以及从全身性疾病中分离出的频率之间的关系。在学龄前儿童中，14型和18型，以及5岁以上患者中的1型、4型、7型、8型和12型，与全身性疾病显著相关；而学龄前儿童中的23型和老年患者中的6型，与上呼吸道携带相关。与上呼吸道携带相比，其他血清型在全身性疾病中的发病率没有显著差异。15种诊断性肺炎球菌抗血清（针对1型、3型、4型、6型、7型、8型、9型、11型、12型、14型、17型、18型、19型、22型和23型）足以对87%的菌株进行分型。
