Hayashida M, Yu B P, Masoro E J, Iwasaki K, Ikeda T
Exp Gerontol. 1986;21(6):535-53. doi: 10.1016/0531-5565(86)90006-9.
The changes with age in the ultrastructure of the kidneys were explored in ad libitum fed rats with restricted food intake started soon after weaning or started in young adult life or limited to early life and in rats restricted in protein but not caloric intake. Many ultrastructural changes occurred with age both in the glomeruli and the tubules. Food restriction started soon after weaning or in adult life modulated most of these age changes. By providing detailed information on basement membrane and tubular cell structure, these findings complement previous light microscopic and functional studies in regard to the effects of food restriction on progressive kidney disease in the rat. Food restriction limited to early life and protein restriction without caloric restriction were less effective in modulating these age changes in kidney ultrastructure than food restriction initiated at 6 weeks or 6 months of age and continued for the rest of the life span.
在随意进食的大鼠中，研究了断奶后不久开始、成年后开始或仅限于幼年开始的食物摄入受限以及蛋白质摄入受限但热量摄入不受限的大鼠肾脏超微结构随年龄的变化。随着年龄增长，肾小球和肾小管均出现许多超微结构变化。断奶后不久或成年后开始的食物限制调节了这些年龄变化中的大部分。通过提供关于基底膜和肾小管细胞结构的详细信息，这些发现补充了先前关于食物限制对大鼠进行性肾病影响的光学显微镜和功能研究。与6周或6个月龄开始并持续至整个寿命期的食物限制相比，仅限于幼年的食物限制和无热量限制的蛋白质限制在调节肾脏超微结构的这些年龄变化方面效果较差。
