Fagni L, Zinebi F, Hugon M
Exp Brain Res. 1987;65(3):513-9. doi: 10.1007/BF00235974.
High pressures of helium affect the physiology of the central nervous system in animals and humans. We examined these effects in rat hippocampal slices. The in vitro preparation displayed a reversible reduction in postsynaptic and antidromic field potentials of CA1 pyramidal cells, but no significant change in the amplitude of the afferent volley. Although the subliminal synaptic response of CA1 neurons was depressed, the ability of these cells to produce population spikes was enhanced. These changes resembled those previously found in vivo in the rat hippocampus. The present results support the hypothesis of a helium pressure-induced depolarization of hippocampal neurons. Other possible mechanisms are discussed.
高压氦气会影响动物和人类中枢神经系统的生理机能。我们在大鼠海马体切片中研究了这些影响。体外实验显示，CA1锥体细胞的突触后和逆向场电位出现可逆性降低，但传入冲动的幅度没有显著变化。虽然CA1神经元的阈下突触反应受到抑制，但其产生群体峰电位的能力增强。这些变化与之前在大鼠海马体中发现的体内变化相似。目前的结果支持氦气压力诱导海马体神经元去极化的假说。还讨论了其他可能的机制。
