Rostain J C, Dumas J C, Gardette B, Imbert J P, Lemaire C
J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug;57(2):332-40. doi: 10.1152/jappl.1984.57.2.332.
A series of dives was carried out to depths of 600 and 800 m seawater (msw) using baboons (Papio papio). Experiments were designed to study the effects of compression and the use of a He-N2-O2 gas mixture on high-pressure nervous syndrome (HPNS). When N2 was added to the He-O2 mixture at the beginning of a linear compression (200 msw/h), the symptoms associated with HPNS were still seen; in addition, the electroencephalogram (EEG) changes were more severe than those seen without N2. By use of an identical mixture, a 2-h exponential compression to 600 msw produced less severe signs of HPNS than the nonexponential profile. By use of a 2-h exponential compression to 600 msw and with addition of N2 at the end of compression, the HPNS that had been started under the He-O2 mixture decreased. Progressive addition of N2 during compression reduced the behavioral signs of HPNS without further EEG changes. These results show that the action of N2 is more complex than can be explained by a simple narcotic pressure antagonism and that the HPNS differed according to the gas mixture used.
使用狒狒（豚尾狒狒）进行了一系列潜水至600米和800米海水深度（msw）的实验。实验旨在研究压缩以及使用氦 - 氮 - 氧气体混合物对高压神经综合征（HPNS）的影响。当在直线压缩（200米海水深度/小时）开始时向氦 - 氧混合物中添加氮气时，仍会出现与HPNS相关的症状；此外，脑电图（EEG）变化比不添加氮气时更严重。使用相同的混合物，2小时指数压缩至600米海水深度产生的HPNS症状比非指数压缩情况更轻。通过2小时指数压缩至600米海水深度并在压缩结束时添加氮气，在氦 - 氧混合物下开始出现的HPNS有所减轻。在压缩过程中逐步添加氮气可减少HPNS的行为症状，且脑电图无进一步变化。这些结果表明，氮气的作用比简单的麻醉压力拮抗作用更为复杂，并且HPNS因所用气体混合物的不同而有所差异。
