Fagni L, Zinebi F, Hugon M
GS de Physiologie Hyperbare C.N.R.S., Faculté de Médecine Nord, Marseille, France.
Neurosci Lett. 1987 Oct 29;81(3):285-90. doi: 10.1016/0304-3940(87)90397-1.
We examined the influence of helium pressure on the depression induced by various excitatory amino acids in CA1 hippocampal field potentials. The effects of quisqualate, L-glutamate, L-aspartate and kainate were not significantly affected by helium pressure, while those of N-methyl-D-aspartate and D,L-homocysteate were enhanced. These findings suggest that helium pressure specifically increased the sensitivity of the N-methyl-D-aspartate receptor type in the hippocampus. Other hypotheses are discussed.
我们研究了氦气压力对海马CA1区场电位中各种兴奋性氨基酸诱导的抑制作用的影响。鹌鹑酸、L-谷氨酸、L-天冬氨酸和红藻氨酸的作用不受氦气压力的显著影响，而N-甲基-D-天冬氨酸和D,L-高半胱氨酸的作用则增强。这些发现表明，氦气压力特异性地增加了海马中N-甲基-D-天冬氨酸受体类型的敏感性。还讨论了其他假说。
