硬骨鱼中垂体前叶直接受神经内分泌GABA能控制的形态学证据。

Morphological evidence for a direct neuroendocrine GABAergic control of the anterior pituitary in teleosts.

作者信息

Kah O, Dubourg P, Martinoli M G, Geffard M, Calas A

出版信息

Experientia. 1987 Mar 15;43(3):300-2. doi: 10.1007/BF01945558.

DOI:10.1007/BF01945558

Abstract

The anterior pituitary of teleosts is unique among vertebrates in receiving a direct innervation which represents the morphological support of the neuroendocrine control of pars distalis functions. The participation of GABAergic fibers in this innervation was studied by means of immunocytochemistry at the light and electron microscopic levels, using antibodies against GABA. Immunoreactive fibers, characterized by the presence of small clear and dense cored vesicles, were detected in all parts of the gland. Immunopositive terminals were found in close, sometimes synaptic-like, contact with most glandular cell types in the anterior lobe. The data strongly suggest that in teleosts, as in mammals, GABA is involved in the neuroendocrine control of anterior pituitary functions.

摘要

硬骨鱼的腺垂体在脊椎动物中独具特色，它接受直接的神经支配，这为远侧部功能的神经内分泌控制提供了形态学支持。利用抗γ-氨基丁酸（GABA）抗体，通过光镜和电镜水平的免疫细胞化学方法，研究了GABA能纤维在这种神经支配中的参与情况。在腺垂体的所有部位均检测到了具有小而清亮和致密核心囊泡的免疫反应性纤维。在前叶中，发现免疫阳性终末与大多数腺细胞类型紧密接触，有时呈突触样接触。这些数据有力地表明，在硬骨鱼中，如同在哺乳动物中一样，GABA参与腺垂体功能的神经内分泌控制。