Janowiak-Majeranowska Aleksandra, Osowski Jakub, Mikaszewski Bogusław, Majeranowski Alan
Department of Otolaryngology, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Students' Scientific Association, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Cancers (Basel). 2022 Apr 27;14(9):2175. doi: 10.3390/cancers14092175.
(1) Purpose: In this article, the authors decided to systematically review the available literature to identify potential correlations regarding secondary oral carcinoma occurring after hematological systemic treatment and oral chronic graft-versus-host disease. (2) Methods: Medline (PubMed) and Scopus (Elsevier) databases were searched, including articles from the years 2002-2022. The 33 unique results were assessed by a PRISMA flowchart, and we rejected 24 papers and included 9 articles in the review. (3) Results: The majority of patients suffered from the oral form of chronic graft-versus-host disease before the diagnosis of oral malignancy. Two common cancer sites were the tongue and buccal mucosa. The exact percentage of secondary oral carcinoma after hematopoietic stem cell transplantation could not be estimated due to a lack of data. (4) Conclusions: Every physician taking part in the follow-up of patients after hematological treatment should be aware of the possibility of secondary neoplastic disease in the oral cavity, especially in patients with oral graft-versus-host disease. Proper follow-up protocols and monitoring are needed in this patient group as the cause of these cancers appears to be multifactorial.
(1) 目的：在本文中，作者决定系统回顾现有文献，以确定血液系统全身治疗后发生的继发性口腔癌与口腔慢性移植物抗宿主病之间的潜在关联。(2) 方法：检索了Medline（PubMed）和Scopus（爱思唯尔）数据库，包括2002年至2022年的文章。通过PRISMA流程图对33个独特结果进行评估，我们排除了24篇论文，纳入9篇文章进行综述。(3) 结果：大多数患者在口腔恶性肿瘤诊断之前患有口腔形式的慢性移植物抗宿主病。两个常见的癌症部位是舌和颊黏膜。由于缺乏数据，无法估计造血干细胞移植后继发性口腔癌的确切百分比。(4) 结论：每一位参与血液系统治疗后患者随访的医生都应意识到口腔发生继发性肿瘤疾病的可能性，尤其是患有口腔移植物抗宿主病的患者。由于这些癌症的病因似乎是多因素的，因此该患者群体需要适当的随访方案和监测。
