Li Duo, Shan Yidan, Sun Weilian, Wang Xiangjian
Department of Oral Medicine, The Affiliated People's Hospital of Ningbo University, Ningbo, CHN.
Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, CHN.
Cureus. 2024 Sep 26;16(9):e70233. doi: 10.7759/cureus.70233. eCollection 2024 Sep.
Hematopoietic stem cell transplantation (HSCT) is the standard treatment for hematopoietic malignancies and certain solid tumors; however, graft-versus-host disease (GVHD) remains a significant complication. Chronic GVHD (cGVHD), which occurs more than 100 days post-transplant, can lead to various oral manifestations that necessitate multidisciplinary management to prevent disease progression and enhance the quality of life. We present the case of a 60-year-old woman who developed dry mouth, oral pain, a brown-yellow tongue, and dental caries seven years after receiving HLA-matched unrelated donor HSCT. Examination revealed a brown-yellow hairy tongue, extensive tooth decay, reduced saliva production, and oral leukoplakia with mild epithelial hyperplasia, along with dysfunction of the salivary and lacrimal glands. Following appropriate treatment, the patient's symptoms resolved without recurrence at the six-month follow-up. This case highlights the importance of professional diagnosis, timely interventions, and regular monitoring in managing oral cGVHD to achieve a favorable prognosis.
造血干细胞移植（HSCT）是治疗造血系统恶性肿瘤和某些实体瘤的标准方法；然而，移植物抗宿主病（GVHD）仍然是一个严重的并发症。慢性移植物抗宿主病（cGVHD）发生在移植后100天以上，可导致各种口腔表现，需要多学科管理以防止疾病进展并提高生活质量。我们报告一例60岁女性病例，她在接受HLA匹配的无关供体造血干细胞移植7年后出现口干、口腔疼痛、棕黄色舌苔和龋齿。检查发现有棕黄色毛状舌苔、广泛的龋齿、唾液分泌减少、伴有轻度上皮增生的口腔白斑，以及唾液腺和泪腺功能障碍。经过适当治疗，患者症状缓解，在六个月的随访中未复发。该病例强调了专业诊断、及时干预和定期监测在管理口腔慢性移植物抗宿主病以获得良好预后方面的重要性。
