Cascallar María, Alijas Sandra, Pensado-López Alba, Vázquez-Ríos Abi Judit, Sánchez Laura, Piñeiro Roberto, de la Fuente María
Nano-Oncology and Translational Therapeutics Group, Health Research Institute of Santiago de Compostela (IDIS), SERGAS, 15706 Santiago de Compostela, Spain.
Centro de Investigación Biomédica en Red Cáncer (CIBERONC), 28029 Madrid, Spain.
Cancers (Basel). 2022 Apr 30;14(9):2238. doi: 10.3390/cancers14092238.
Cancer causes millions of deaths each year and thus urgently requires the development of new therapeutic strategies. Nanotechnology-based anticancer therapies are a promising approach, with several formulations already approved and in clinical use. The evaluation of these therapies requires efficient in vivo models to study their behavior and interaction with cancer cells, and to optimize their properties to ensure maximum efficacy and safety. In this way, zebrafish is an important candidate due to its high homology with the human genoma, its large offspring, and the ease in developing specific cancer models. The role of zebrafish as a model for anticancer therapy studies has been highly evidenced, allowing researchers not only to perform drug screenings but also to evaluate novel therapies such as immunotherapies and nanotherapies. Beyond that, zebrafish can be used as an "avatar" model for performing patient-derived xenografts for personalized medicine. These characteristics place zebrafish in an attractive position as a role model for evaluating novel therapies for cancer treatment, such as nanomedicine.
癌症每年导致数百万人死亡，因此迫切需要开发新的治疗策略。基于纳米技术的抗癌疗法是一种很有前景的方法，已有几种制剂获批并应用于临床。对这些疗法的评估需要高效的体内模型，以研究它们与癌细胞的行为和相互作用，并优化其特性，以确保最大疗效和安全性。在这方面，斑马鱼是一个重要的候选者，因为它与人类基因组具有高度同源性、后代数量多，且易于建立特定的癌症模型。斑马鱼作为抗癌治疗研究模型的作用已得到充分证明，这使研究人员不仅能够进行药物筛选，还能评估免疫疗法和纳米疗法等新型疗法。除此之外，斑马鱼可用作“化身”模型，用于进行患者来源的异种移植，以实现个性化医疗。这些特性使斑马鱼成为评估癌症治疗新疗法（如纳米医学）的理想模型。
