Smart Biodevices for NanoMed Group, University of Valladolid, LUCIA Building, 47011 Valladolid, Spain.
BIOFORGE Research Group (Group for Advanced Materials and Nanobiotechnology), CIBER-BBN, University of Valladolid, LUCIA Building, 47011 Valladolid, Spain.
Int J Pharm. 2021 Apr 15;599:120438. doi: 10.1016/j.ijpharm.2021.120438. Epub 2021 Mar 2.
Cancer has reached pandemic dimensions in the whole world. Although current medicine offers multiple treatment options against cancer, novel therapeutic strategies are needed due to the low specificity of chemotherapeutic drugs, undesired side effects and the presence of different incurable types of cancer. Among these new strategies, nanomedicine arises as an encouraging approach towards personalized medicine with high potential for present and future cancer patients. Therefore, nanomedicine aims to develop novel tools with wide potential in cancer treatment, imaging or even theranostic purposes. Even though numerous preclinical studies have been published with successful preliminary results, promising nanosystems have to face multiple obstacles before adoption in clinical practice as safe options for patients with cancer. In this MiniReview, we provide a short overview on the latest advances in current nanomedicine approaches, challenges and promising strategies towards more accurate cancer treatment.
癌症在全球范围内已经达到了流行的程度。尽管目前的医学提供了多种治疗癌症的选择，但由于化疗药物的特异性低、不良反应不可取以及存在不同类型的不治之症，需要新的治疗策略。在这些新策略中，纳米医学作为一种有前途的个体化治疗方法出现，对当前和未来的癌症患者具有巨大的潜力。因此，纳米医学旨在开发具有广泛潜力的新型工具，用于癌症治疗、成像甚至治疗目的。尽管已经发表了许多具有初步成功结果的临床前研究，但有前途的纳米系统在被采纳为癌症患者的安全选择之前，必须克服许多障碍，才能在临床实践中应用。在这篇综述中，我们简要概述了当前纳米医学方法的最新进展、挑战和有前途的策略，以实现更精确的癌症治疗。
