Szymoński Krzysztof, Milian-Ciesielska Katarzyna, Lipiec Ewelina, Adamek Dariusz
Department of Pathomorphology, Jagiellonian University Medical College, 31-531 Cracow, Poland.
Department of Pathomorphology, University Hospital, 30-688 Cracow, Poland.
Cancers (Basel). 2022 May 7;14(9):2321. doi: 10.3390/cancers14092321.
Pancreatic cancer (PC) is one of the most aggressive and lethal malignant neoplasms, ranking in seventh place in the world in terms of the incidence of death, with overall 5-year survival rates still below 10%. The knowledge about PC pathomechanisms is rapidly expanding. Daily reports reveal new aspects of tumor biology, including its molecular and morphological heterogeneity, explain complicated "cross-talk" that happens between the cancer cells and tumor stroma, or the nature of the PC-associated neural remodeling (PANR). Staying up-to-date is hard and crucial at the same time. In this review, we are focusing on a comprehensive summary of PC aspects that are important in pathologic reporting, impact patients' outcomes, and bring meaningful information for clinicians. Finally, we show promising new trends in diagnostic technologies that might bring a difference in PC early diagnosis.
胰腺癌（PC）是最具侵袭性和致死性的恶性肿瘤之一，在全球死亡发病率中排名第七，总体5年生存率仍低于10%。关于胰腺癌发病机制的知识正在迅速扩展。每日报告揭示了肿瘤生物学的新方面，包括其分子和形态学异质性，解释了癌细胞与肿瘤基质之间复杂的“相互作用”，或胰腺癌相关神经重塑（PANR）的本质。紧跟最新进展既困难又至关重要。在这篇综述中，我们重点全面总结了胰腺癌在病理报告中重要、影响患者预后并为临床医生带来有意义信息的各个方面。最后，我们展示了诊断技术中可能对胰腺癌早期诊断产生影响的有前景的新趋势。
