Nam Seungyoon, Lee Yongmin
Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences and Technology (GAIHST), Gachon University, Incheon 21999, Korea.
Department of Genome Medicine and Science, AI Convergence Center for Medical Science, Gachon Institute of Genome Medicine and Science, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon 21565, Korea.
Cancers (Basel). 2022 May 9;14(9):2340. doi: 10.3390/cancers14092340.
Gastric cancer (GC) is one of the most lethal cancers worldwide; it has a high mortality rate, particularly in East Asia. Recently, genetic events (e.g., mutations and copy number alterations) and molecular signaling associated with histologically different GC subtypes (diffuse and intestinal) have been elucidated. However, metabolic differences among the histological GC subtypes have not been studied systematically. In this study, we utilized transcriptome-based genome-scale metabolic models (GEMs) to identify differential metabolic pathways between Lauren diffuse and intestinal subtypes. We found that diverse metabolic pathways, including cholesterol homeostasis, xenobiotic metabolism, fatty acid metabolism, the MTORC1 pathway, and glycolysis, were dysregulated between the diffuse and intestinal subtypes. Our study provides an overview of the metabolic differences between the two subtypes, possibly leading to an understanding of metabolism in GC heterogeneity.
胃癌（GC）是全球最致命的癌症之一；其死亡率很高，尤其是在东亚地区。最近，与组织学上不同的GC亚型（弥漫型和肠型）相关的遗传事件（如突变和拷贝数改变）及分子信号传导已得到阐明。然而，组织学GC亚型之间的代谢差异尚未得到系统研究。在本研究中，我们利用基于转录组的基因组规模代谢模型（GEMs）来识别劳伦弥漫型和肠型亚型之间的差异代谢途径。我们发现，包括胆固醇稳态、异生物代谢、脂肪酸代谢、mTORC1途径和糖酵解在内的多种代谢途径在弥漫型和肠型亚型之间失调。我们的研究概述了这两种亚型之间的代谢差异，可能有助于理解GC异质性中的代谢情况。
