Il'iuchenok T Iu, Matveeva I A, Budagov R O
Farmakol Toksikol. 1987 Jan-Feb;50(1):71-4.
Toxic and pharmacological properties of promedol, droperidol and dimedrol were studied during burn shock and combined radiation and thermal injury (CRTI). Acute toxicity and analgesic effect of promedol were shown to increase in the given period Droperidol analgesic effect enhanced in burn and CRTI, cataleptic action enhanced only in CRTI. A decrease of antihistaminic activity of dimedrol was more pronounced in CRTI.
在烧伤休克以及复合辐射与热损伤(CRTI)期间,研究了异丙嗪、氟哌利多和苯海拉明的毒性及药理特性。结果显示,在上述时期,异丙嗪的急性毒性和镇痛作用增强。氟哌利多的镇痛作用在烧伤和CRTI时增强,其安定作用仅在CRTI时增强。苯海拉明的抗组胺活性降低在CRTI时更为明显。