Ardentova N N
Farmakol Toksikol. 1980 Jan-Feb;43(1):23-9.
It was shown in experiments on white rats that the intensity of the antitoxic action of nalorphine (0.57 mg/kg) and pentazocin (3 mg/kg) is related to the chemical structure of a narcotic analgetic agent. This action is more clearly manifested during poisoning induced by the phenylpiperidine derivative promedol (LD50 33.33 mg/kg). Nalorphine increases LD50 of promedol and corrects of metabolic disturbances produced by promedol. Pentazocin does not compare favourably to nalorphine since it mostly acts as a stimulant of external respiration.
在对白鼠的实验中发现，烯丙吗啡（0.57毫克/千克）和喷他佐辛（3毫克/千克）的抗毒作用强度与麻醉性镇痛药的化学结构有关。在苯哌啶衍生物普罗美多（半数致死量33.33毫克/千克）所致中毒时，这种作用表现得更为明显。烯丙吗啡可提高普罗美多的半数致死量，并纠正普罗美多引起的代谢紊乱。喷他佐辛与烯丙吗啡相比效果不佳，因为它主要起刺激外呼吸的作用。
