Dmitriev A V, Bershadskiĭ B G
Farmakol Toksikol. 1984 Jul-Aug;47(4):34-6.
A comprehensive approach is suggested to the assessment of the analgetic action of analgetics during screening. This approach lies in the study of the drug effects on the emotional, vegetative and motor manifestations of the painful reactions. Based on multiple and regression analysis the role of different factors of the initial status of the body in the development of analgesia is demonstrated. Application of the given approach is examplified by the reference analgetic promedol.
建议在筛选过程中采用综合方法评估镇痛药的镇痛作用。这种方法在于研究药物对疼痛反应的情绪、自主神经和运动表现的影响。基于多元回归分析，证明了身体初始状态的不同因素在镇痛作用产生过程中的作用。以参考镇痛药异丙嗪为例说明了该方法的应用。
