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宫内编程概念与新生儿微生物组在预防 SARS-CoV-2 感染中的发展。

The Concept of Intrauterine Programming and the Development of the Neonatal Microbiome in the Prevention of SARS-CoV-2 Infection.

机构信息

Department of Epidemiology, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.

Department of Public Health, Department of Public Health Policy, Faculty of Health Sciences in Bytom, Medical University of Silesia in Katowice, 41-902 Bytom, Poland.

出版信息

Nutrients. 2022 Apr 20;14(9):1702. doi: 10.3390/nu14091702.

DOI:10.3390/nu14091702
PMID:35565670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9104449/
Abstract

The process of intrauterine programming is related to the quality of the microbiome formed in the fetus and the newborn. The implementation of probiotics, prebiotics, and psychobiotics shows immunomodulatory potential towards the organism, especially the microbiome of the pregnant woman and her child. Nutrigenomics, based on the observation of pregnant women and the developing fetus, makes it possible to estimate the biological effects of active dietary components on gene expression or silencing. Nutritional intervention for pregnant women should consider the nutritional status of the patient, biological markers, and the potential impact of dietary intervention on fetal physiology. The use of a holistic model of nutrition allows for appropriately targeted and effective dietary prophylaxis that can impact the physical and mental health of both the mother and the newborn. This model targets the regulation of the immune response of the pregnant woman and the newborn, considering the clinical state of the microbiota and the pathomechanism of the nervous system. Current scientific reports indicate the protective properties of immunobiotics (probiotics) about the reduction of the frequency of infections and the severity of the course of COVID-19 disease. The aim of this study was to test the hypothesis that intrauterine programming influences the development of the microbiome for the prevention of SARS-CoV-2 infection based on a review of research studies.

摘要

宫内编程过程与胎儿和新生儿形成的微生物组的质量有关。益生菌、益生元和心理益生菌的应用表现出对机体的免疫调节潜力，特别是孕妇及其儿童的微生物组。基于对孕妇和发育中胎儿的观察，营养基因组学使得可以估计活性饮食成分对基因表达或沉默的生物学影响。孕妇的营养干预应考虑患者的营养状况、生物标志物以及饮食干预对胎儿生理的潜在影响。使用整体营养模型可以进行有针对性和有效的饮食预防，从而影响母婴的身心健康。该模型针对调节孕妇和新生儿的免疫反应，同时考虑到微生物组的临床状态和神经系统的发病机制。目前的科学报告表明免疫生物制剂（益生菌）具有降低 COVID-19 疾病感染频率和严重程度的保护特性。本研究旨在通过对研究文献的回顾，检验宫内编程影响微生物组发育以预防 SARS-CoV-2 感染的假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/ed7048e0a1a4/nutrients-14-01702-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/c9e746670aa9/nutrients-14-01702-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/14622d057ba5/nutrients-14-01702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/c521d48e2059/nutrients-14-01702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/ed7048e0a1a4/nutrients-14-01702-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/c9e746670aa9/nutrients-14-01702-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/fccaecb54b1a/nutrients-14-01702-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/0196a1ef3457/nutrients-14-01702-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/14622d057ba5/nutrients-14-01702-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/c521d48e2059/nutrients-14-01702-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c455/9104449/ed7048e0a1a4/nutrients-14-01702-g006.jpg

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Gut microbiota changes are detected in asymptomatic very young children with SARS-CoV-2 infection.在无症状的新冠病毒感染幼儿中检测到肠道微生物群变化。
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儿童哮喘与非哮喘患者的呼吸症状、过敏和环境暴露情况。
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