Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.
Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea.
Nutrients. 2022 Apr 22;14(9):1747. doi: 10.3390/nu14091747.
Sarcopenia and obesity are serious health problems that are highly related to several metabolic diseases. Sarcopenic obesity, a combined state of sarcopenia and obesity, results in higher risks of metabolic diseases and even mortality than sarcopenia or obesity alone. Therefore, the development of therapeutic agents for sarcopenic obesity is crucial. C57BL/6 mice were fed with a high-fat diet (HFD) for 9 weeks. Then, mice were administered with Panax ginseng berry extract (GBE) for an additional 4 weeks, with continuous HFD intake. GBE significantly decreased the food efficiency ratio, serum lipid and insulin levels, adipose tissue weights, and adipocyte size. It significantly increased the grip strength, muscle masses, and myofiber cross-sectional area. It deactivated the protein kinase C (PKC) theta and zeta, resulting in activation of the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) pathway, which is known to regulate muscle synthesis and degradation. Furthermore, it inhibited the production of inflammatory cytokines in the muscle tissue. GBE attenuated both obesity and sarcopenia. Thus, GBE is a potential agent to prevent or treat sarcopenic obesity.
肌少症和肥胖是严重的健康问题，与多种代谢性疾病密切相关。肌少症合并肥胖是肌少症和肥胖的共同状态，其发生代谢性疾病甚至死亡的风险高于单纯的肌少症或肥胖。因此，开发肌少症合并肥胖的治疗药物至关重要。C57BL/6 小鼠用高脂肪饮食（HFD）喂养 9 周。然后，连续给予 HFD 的同时，再给予小鼠人参果提取物（GBE）4 周。GBE 显著降低了食物效率比、血清脂质和胰岛素水平、脂肪组织重量和脂肪细胞大小。它显著增加了握力、肌肉质量和肌纤维横截面积。它使蛋白激酶 C（PKC）θ和ζ失活，导致磷酸肌醇 3-激酶（PI3K）/蛋白激酶 B（Akt）通路的激活，该通路已知可调节肌肉的合成和降解。此外，它还抑制了肌肉组织中炎症细胞因子的产生。GBE 减轻了肥胖和肌少症。因此，GBE 是预防或治疗肌少症合并肥胖的潜在药物。
