Yoon Dasom, Bae Hyunhwa, Park Hyoung Su, Kim Hyejin, Auh Joong-Hyuck, Kim Don-Kyu
Department of Physical and Rehabilitation Medicine, Chung-Ang University Gwangmyeong Hospital, Gwangmyeong 14353, Korea.
Department of Food Science and Biotechnology, Chung-Ang University, Anseong 17546, Korea.
Nutr Res Pract. 2025 Jun;19(3):412-424. doi: 10.4162/nrp.2025.19.3.412. Epub 2025 Feb 18.
BACKGROUND/OBJECTIVES: Sarcopenia can be prevented or mitigated through appropriate nutrition supplementation combined with exercise. We assessed the effects of 12-week supplementation with a mixture of low-molecular-weight whey protein hydrolysate (LMWPH) and ginseng berry extract (GBE), combined with resistance exercises, on muscle strength and physical performance in healthy Korean adults aged 60 yrs or older.
SUBJECTS/METHODS: This randomized, double-blind, placebo-controlled trial enrolled 100 participants aged 60 yrs or older, who were assigned to either the LMWPH-GBE group (5,000 mg/d, including LMWPH-GBE 4,500 mg) or placebo group. Participants performed lower-extremity strengthening exercises for 30-60 min at least 3 days per week. Handgrip strength, knee extensor muscle strength, muscle power and physical performance using short physical performance battery (SPPB), body composition, including appendicular skeletal muscle mass, skeletal muscle mass index, body mass index, fat mass and percentage, were assessed using dual energy absorptiometry.
The LMWPH-GBE group showed significant improvements in right-handgrip strength (0.53 ± 2.82 kg, = 0.027) and total SPPB scores (0.18 ± 0.45 points, = 0.049) compared with the placebo (-0.83 ± 2.86 kg and -0.05±0.61 points, respectively). Additionally, the LMWPH-GBE group demonstrated improvements in the SPPB subscale compared with the placebo, with the 4-m gait speed changed by 0.26 ± 0.37 m/s (placebo: -0.02 ± 0.31 m/s, < 0.001) and repeated chair stand time changed by -2.30 ± 1.78 s (placebo: -0.06 ± 1.60 s, < 0.001). Knee extensor strength, muscle power, and muscle mass did not significantly differ between groups, likely because both groups performed lower-extremity strengthening exercises over 12 weeks.
Twelve weeks of LMWPH-GBE supplementation improved physical performance and muscle strength, particularly right-handgrip strength, in older adults. Low-dose protein (LMWPH) and botanical extract (GBE) supplementation shows potential as a practical dietary intervention for older individuals who may not tolerate higher protein doses.
背景/目的：通过适当的营养补充剂与运动相结合，可以预防或减轻肌肉减少症。我们评估了12周补充低分子量乳清蛋白水解物（LMWPH）与人参果提取物（GBE）的混合物，并结合抗阻运动，对60岁及以上健康韩国成年人肌肉力量和身体机能的影响。
受试者/方法：这项随机、双盲、安慰剂对照试验招募了100名60岁及以上的参与者，他们被分配到LMWPH-GBE组（5000毫克/天，包括LMWPH-GBE 4500毫克）或安慰剂组。参与者每周至少3天进行30-60分钟的下肢强化运动。使用握力、膝伸肌力量、肌肉功率和简短体能状况量表（SPPB）评估身体机能，使用双能X线吸收法评估身体成分，包括四肢骨骼肌质量、骨骼肌质量指数、体重指数、脂肪量和百分比。
与安慰剂组相比，LMWPH-GBE组右手握力（0.53±2.82千克，P = 0.027）和SPPB总分（0.18±0.45分，P = 0.049）有显著改善（安慰剂组分别为-0.83±2.86千克和-0.05±0.61分）。此外，与安慰剂组相比，LMWPH-GBE组在SPPB子量表方面有所改善，4米步行速度变化了0.26±0.37米/秒（安慰剂组：-0.02±0.31米/秒，P<0.001），重复坐立试验时间变化了-2.30±1.78秒（安慰剂组：-0.06±1.60秒，P<0.001）。两组之间的膝伸肌力量、肌肉功率和肌肉质量没有显著差异，可能是因为两组在12周内都进行了下肢强化运动。
12周的LMWPH-GBE补充剂改善了老年人的身体机能和肌肉力量，尤其是右手握力。低剂量蛋白质（LMWPH）和植物提取物（GBE）补充剂显示出作为一种实用饮食干预措施的潜力，适用于可能无法耐受更高蛋白质剂量的老年人。
