Pezzino Salvatore, Sofia Maria, Mazzone Chiara, Litrico Giorgia, Greco Luigi Piero, Gallo Luisa, La Greca Gaetano, Latteri Saverio
Department of Surgical Sciences and Advanced Technologies "G. F. Ingrassia", Cannizzaro Hospital, University of Catania, 95123, Catania, Italy.
Heliyon. 2024 Aug 8;10(16):e35498. doi: 10.1016/j.heliyon.2024.e35498. eCollection 2024 Aug 30.
The increasing scientific interest in antioxidants and naturally derived compounds as potential remedies for obesity and non-alcoholic fatty liver disease (NAFLD) has led to extensive research. The objective of this bibliometric analysis is to present an updated perspective on the topic of antioxidants, herbs, phytochemicals, and natural compounds, in the control of obesity and NAFLD, to identify new areas for future research. Publications from the years 2012-2022 were retrieved using the Scopus database. The research trends were analyzed using the Biblioshiny and VOSviewer tools. The field has seen a significant increase in research activity, as indicated by an annual growth rate of 10 % in the number of published manuscripts. China, Korea, and the USA emerged as the most prominent contributors in this specific field, supported by their notable volumes of publications and citations. The density analysis revealed that the most frequently occurring authors' keywords related to herbal species are, in rank order In the group of antioxidants, phytochemicals, and natural compounds, the top 10 were resveratrol, curcumin, quercetin, vitamin E, alpha-lipoic acid, vitamin C, chlorogenic acid, lycopene, fucoxanthin, and berberine. The co-occurrence analysis unveiled significant themes and potential trends, including a notable interest in the impact of herbal species, antioxidants, phytochemicals, and natural compounds on obesity and NAFLD through the modulation of the gut microbiome. Another recurring theme that arises, is the ongoing investigation of molecular targets that demonstrate anti-adipogenesis properties. The analysis presented in this study provides valuable insights for researchers investigating the efficacy of antioxidants, herbs, phytochemicals, and natural compounds in addressing obesity and NAFLD. Through the use of bibliometric methods, the study offers a comprehensive overview. Furthermore, the findings of this analysis can serve as a foundation for future research in this specific domain.
对作为肥胖和非酒精性脂肪性肝病（NAFLD）潜在治疗方法的抗氧化剂和天然衍生化合物的科学兴趣日益浓厚，引发了广泛研究。本文献计量分析的目的是就抗氧化剂、草药、植物化学物质和天然化合物在控制肥胖和NAFLD方面的主题提供最新观点，以确定未来研究的新领域。使用Scopus数据库检索了2012年至2022年的出版物。使用Biblioshiny和VOSviewer工具分析了研究趋势。该领域的研究活动显著增加，发表的手稿数量年增长率为10%。中国、韩国和美国成为这一特定领域最突出的贡献者，其出版物和被引次数显著。密度分析显示，与草药种类相关的最常出现的作者关键词按排名顺序排列。在抗氧化剂、植物化学物质和天然化合物组中，排名前十的是白藜芦醇、姜黄素、槲皮素、维生素E、α-硫辛酸、维生素C、绿原酸、番茄红素、岩藻黄质和小檗碱。共现分析揭示了重要主题和潜在趋势，包括对草药种类、抗氧化剂、植物化学物质和天然化合物通过调节肠道微生物群对肥胖和NAFLD的影响的显著兴趣。另一个反复出现的主题是对具有抗脂肪生成特性的分子靶点的持续研究。本研究中的分析为研究抗氧化剂、草药、植物化学物质和天然化合物在解决肥胖和NAFLD方面功效的研究人员提供了有价值的见解。通过使用文献计量方法，该研究提供了全面的概述。此外，该分析的结果可作为这一特定领域未来研究的基础。
