高血压患者血清抵抗素水平、抵抗素（-420C/G）单核苷酸变异与内皮功能障碍标志物的关系，包括盐味觉偏好。

The Association between Serum Resistin Level, Resistin (-420C/G) Single Nucleotide Variant, and Markers of Endothelial Dysfunction, including Salt Taste Preference in Hypertensive Patients.

机构信息

Department of Treatment of Obesity, Metabolic Disorders, and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569 Poznan, Poland.

Department of Internal Medicine, Metabolic Disorders and Hypertension, Poznan University of Medical Sciences, Szamarzewskiego St. 82/84, 60-569 Poznan, Poland.

出版信息

Nutrients. 2022 Apr 24;14(9):1789. doi: 10.3390/nu14091789.

DOI:10.3390/nu14091789

PMID:35565757

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9102533/

Abstract

Resistin action links to conditions such as diabetes, obesity, but its role in hypertension is less well understood. This study aimed to estimate the relationship between resistin (-420G/C) single nucleotide variant (SNV) and markers associated with endothelial dysfunction in hypertension. The study enrolled 162 hypertensive patients (HT) and 165 non-hypertensive (NHT) patients. Resistin serum concentration was estimated with immuoenzymatic assay. Anthropometric measurements, blood pressure and arterial stiffness index (SI), uric acid (UA) serum concentration, and salty taste preference of normal (NS) or high (HS) were assessed in the study. Genotyping was achieved by polymerase chain reaction-restriction fragment length polymorphism. Resistin concentration and SI do not differ significantly between HT and NHT individuals; UA significantly increased in HT subjects. Resistin, UA, and SI did not differ among particular resistin genotypes in HT, NHT, NS, or HS groups. GG and CG genotypes were more frequent (OR 1.57 (95% CI; 1.01-2.43); = 0.04) in hypertensive individuals than the NHT group, but less frequent (OR 0.58 (95% CI; 0.37-0.91); = 0.01) in HS patients compared to NS individuals. Concerning HT patients with different salt preferences, GG + CG genotypes were less frequent (OR 0.50 (95% CI; 0.26-0.97); = 0.04) in the HS group than in NS individuals. HT carriers of GG and CG genotype have significantly increased UA concentrations compared to the respective NHT subjects. HS individuals carrying GG and CG genotypes have higher SI values than the NS group. Allele G of SNV (-420G/C) adjusted for age, BMI, serum resistin, UA concentration, salt taste preference, SI, and HR values increased the risk of developing hypertensive phenotype 1.8 fold. Resistin SNV (-420G/C) is related to several markers associated with endothelial dysfunction, including salt taste preference in hypertensive patients.

摘要

抵抗素与糖尿病、肥胖等疾病有关，但它在高血压中的作用尚不清楚。本研究旨在评估抵抗素（-420G/C）单核苷酸变异（SNV）与高血压患者内皮功能障碍相关标志物之间的关系。该研究纳入了 162 名高血压患者（HT）和 165 名非高血压患者（NHT）。采用免疫酶联法测定抵抗素血清浓度。评估研究对象的人体测量学指标、血压和动脉僵硬度指数（SI）、尿酸（UA）血清浓度以及正常（NS）或高（HS）盐味偏好。通过聚合酶链反应-限制性片段长度多态性实现基因分型。HT 和 NHT 个体之间的抵抗素浓度和 SI 无显著差异；HT 患者的 UA 显著升高。HT、NHT、NS 和 HS 组中，特定抵抗素基因型之间的抵抗素、UA 和 SI 无差异。与 NHT 组相比，GG 和 CG 基因型在高血压患者中更为常见（OR 1.57（95%CI；1.01-2.43）； = 0.04），而在 HS 患者中比 NS 个体更为少见（OR 0.58（95%CI；0.37-0.91）； = 0.01）。对于不同盐味偏好的 HT 患者，与 NS 个体相比，HS 组的 GG + CG 基因型更为少见（OR 0.50（95%CI；0.26-0.97）； = 0.04）。与各自的 NHT 相比，携带 GG 和 CG 基因型的 HT 患者的 UA 浓度显著升高。携带 GG 和 CG 基因型的 HS 个体的 SI 值高于 NS 组。经年龄、BMI、血清抵抗素、UA 浓度、盐味偏好、SI 和 HR 值调整后，SNV（-420G/C）的 G 等位基因使高血压表型的发病风险增加 1.8 倍。抵抗素 SNV（-420G/C）与高血压患者的内皮功能障碍相关标志物有关，包括盐味偏好。