Department of Environmental Physiology, Faculty of Medicine, Shimane University, En-ya-cho 89-1, Izumo 693-8501, Japan.
Department of Applied Biology and Food Sciences, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki 036-8561, Japan.
Nutrients. 2022 Apr 28;14(9):1847. doi: 10.3390/nu14091847.
As life expectancy increases, age-associated diseases such as Alzheimer's disease (AD) become a major health problem. The onset of AD involves neurological dysfunction due to amyloid-β accumulation, tau hyperphosphorylation, oxidative stress, and neuroinflammation in the brain. In addition, lifestyle-related diseases-such as dyslipidemia, diabetes, obesity, and vascular dysfunction-increase the risk of developing dementia. The world population ages, prompting the development of new strategies to maintain brain health and prevent the onset of dementia in older and preclinical patients. Citrus fruits are abundant polymethoxylated flavone and flavanone sources. Preclinical studies reported that these compounds have neuroprotective effects in models of dementia such as AD. Interestingly, clinical and epidemiological studies appear to support preclinical evidence and show improved cognitive function and reduced associated disease risk in healthy individuals and/or patients. This review summarizes the recent evidence of the beneficial effects of citrus peels and extracts on human cognition and related functions.
随着预期寿命的延长，阿尔茨海默病（AD）等与年龄相关的疾病成为一个主要的健康问题。AD 的发病涉及到由于淀粉样蛋白-β的积累、tau 过度磷酸化、氧化应激和大脑中的神经炎症导致的神经功能障碍。此外，与生活方式相关的疾病，如血脂异常、糖尿病、肥胖和血管功能障碍，会增加痴呆的发病风险。随着世界人口老龄化，人们正在开发新的策略来维持大脑健康，预防老年和临床前患者的痴呆症发作。柑橘类水果富含多甲氧基黄酮和黄烷酮。临床前研究报告称，这些化合物在 AD 等痴呆症模型中具有神经保护作用。有趣的是，临床和流行病学研究似乎支持临床前证据，并显示在健康个体和/或患者中改善认知功能和降低相关疾病风险。本综述总结了柑橘果皮和提取物对人类认知和相关功能的有益影响的最新证据。
