Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan.
Sankyo Holdings Co., Ltd, Fuji, Shizuoka, Japan.
Food Funct. 2022 Mar 7;13(5):2768-2781. doi: 10.1039/d1fo03508h.
() seed oil (PO), rich in α-linolenic acid (ALA), can improve cognitive function in healthy elderly Japanese people. Here, supplements containing either PO alone or PO with nobiletin-rich air-dried immature ponkan powder were examined for their effects on cognitive function in 49 healthy elderly Japanese individuals. Patients were enrolled in a 12-month randomized, double-blind, parallel-armed study. Randomized participants in the PO group received soft gelatin capsules containing 1.47 mL (0.88 g of ALA) of PO daily, and those in the PO + ponkan powder (POPP) group received soft gelatin capsules containing both 1.47 mL of PO and 1.12 g ponkan powder (2.91 mg of nobiletin) daily. At the end of intervention, the POPP group showed significantly higher cognitive index scores than the PO group. The pro-cognitive effects of POPP treatment were accompanied by increases in ALA and docosahexaenoic acid levels in red blood cell plasma membranes, serum brain-derived neurotropic factor (BDNF) levels, and biological antioxidant potential. We demonstrate that 12-month intervention with POPP enhances serum BDNF and antioxidant potential, and may improve age-related cognitive impairment in healthy elderly people by increasing red blood cell ω-3 fatty acid levels. Clinical Trial Registry, UMIN000040863.
富含 α-亚麻酸（ALA）的（）籽油（PO）可改善健康日本老年人的认知功能。在此，研究了单独含有 PO 或 PO 与富含川陈皮素的风干未成熟碰柑粉末的补充剂对 49 名健康日本老年人认知功能的影响。患者参加了为期 12 个月的随机、双盲、平行臂研究。PO 组的随机参与者每天服用含有 1.47 毫升（0.88 克 ALA）PO 的软明胶胶囊，PO+碰柑粉末（POPP）组每天服用含有 1.47 毫升 PO 和 1.12 克碰柑粉末（2.91 毫克川陈皮素）的软明胶胶囊。干预结束时，POPP 组的认知指数评分明显高于 PO 组。POPP 治疗的促认知作用伴随着红细胞质膜中 ALA 和二十二碳六烯酸水平、血清脑源性神经营养因子（BDNF）水平和生物抗氧化能力的增加。我们证明，POPP 的 12 个月干预增强了血清 BDNF 和抗氧化能力，并通过增加红细胞 ω-3 脂肪酸水平，可能改善健康老年人的与年龄相关的认知障碍。临床试验注册，UMIN000040863。
