CDI (Centro Diagnostico Italiano), 20147 Milan, Italy.
R&D Department, Indena SpA, 20139 Milan, Italy.
Nutrients. 2022 Apr 29;14(9):1858. doi: 10.3390/nu14091858.
Acute diarrhea is a frequent problem worldwide, mostly due to gastrointestinal infections or food poisoning. Boswellia serrata could be active in the treatment of acute diarrhea due to its anti-inflammatory, antispasmodic, and antimicrobial activity. In this randomized, double-blind, placebo-controlled clinical study, 49 adults with acute diarrhea were randomly allocated to receive 250 mg of a lecithin-based delivery form of Boswellia serrata (CASP) or placebo for 5 days. The time it took to become healthy with stoppage of diarrhea (primary end point) was significantly shorter in the intervention group (3.08 vs. 4.44 days: p-value < 0.0001). The probability of subjects treated with CASP to recover sooner was equal to 80.2%. A significantly lower number of stools was observed in the CASP group over time (β = −0.17, p-value < 0.0001). A significant difference was observed between the two groups for abdominal pain, nausea, and GAE (global assessment of efficacy). In conclusion, the lecithin-based delivery form of Boswellia serrata extract could be a useful addition to the treatment of acute diarrhea in adults. CASP is safe and reduces the time it takes to become healthy, the frequency of stools, the abdominal pain and nausea of subjects with acute diarrhea. Further studies are needed to confirm these promising results.
急性腹泻是全世界范围内常见的问题，主要归因于胃肠道感染或食物中毒。由于乳香具有抗炎、抗痉挛和抗菌活性，因此它可能对治疗急性腹泻有效。在这项随机、双盲、安慰剂对照的临床研究中，49 名急性腹泻的成年人被随机分为两组，分别接受 250 毫克基于卵磷脂的乳香提取物（CASP）或安慰剂治疗 5 天。停止腹泻（主要终点）恢复健康所需的时间在干预组明显更短（3.08 天与 4.44 天：p 值 < 0.0001）。接受 CASP 治疗的患者更早恢复的可能性等于 80.2%。随着时间的推移，CASP 组的粪便次数明显减少（β = −0.17，p 值 < 0.0001）。两组在腹痛、恶心和 GAE（疗效总体评估）方面存在显著差异。总之，基于卵磷脂的乳香提取物的给药形式可能是成人急性腹泻治疗的有效补充。CASP 安全且可缩短恢复健康所需的时间、减少粪便次数、减轻急性腹泻患者的腹痛和恶心症状。需要进一步的研究来证实这些有前景的结果。
